Evidence map›Paper›PMID 33016025›Full record

ArticleJournal of veterinary science2020

Antiviral effects of Bovine antimicrobial peptide against TGEV

Xiuli Liang, Xiaojun Zhang, Kaiqi Lian, Xiuhua Tian, Mingliang Zhang, Shiqiong Wang, Cheng Chen, Cunxi Nie, Yun Pan, Fangfang Han and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Xiuli LiangCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China.ORCID https://orcid.org/0000-0002-0112-0341
Xiaojun ZhangHenan Joint International Research Laboratory of Veterinary Biologics Research and Application, Henan Provincial Animal Disease Prevention and Control and Nutrition Immunization Academician workstation, Anyang Institute of Technology, Anyang, Henan 455000, China.ORCID https://orcid.org/0000-0001-9646-4595
Kaiqi LianHenan Joint International Research Laboratory of Veterinary Biologics Research and Application, Henan Provincial Animal Disease Prevention and Control and Nutrition Immunization Academician workstation, Anyang Institute of Technology, Anyang, Henan 455000, China.ORCID https://orcid.org/0000-0003-0681-207X
Xiuhua TianAnyang County Agricultural and Rural Bureau, Anyang, Henan 455000, China.ORCID https://orcid.org/0000-0002-4929-7939
Mingliang ZhangHenan Joint International Research Laboratory of Veterinary Biologics Research and Application, Henan Provincial Animal Disease Prevention and Control and Nutrition Immunization Academician workstation, Anyang Institute of Technology, Anyang, Henan 455000, China.ORCID https://orcid.org/0000-0002-9512-8781
Shiqiong WangCollege of Animal Husbandry, Henan Agricultural University, Zhengzhou, Henan 450000, China.ORCID https://orcid.org/0000-0002-1719-8223
Cheng ChenCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China.ORCID https://orcid.org/0000-0002-0242-9332
Cunxi NieCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China.ORCID https://orcid.org/0000-0003-3320-2840
Yun PanHenan Yihongshancheng Bio-Tech Co. Ltd, Wuzhi, Henan 454950, China.ORCID https://orcid.org/0000-0002-4529-6736
Fangfang HanCollege of Animal Husbandry, Henan Agricultural University, Zhengzhou, Henan 450000, China.ORCID https://orcid.org/0000-0003-2959-5012
Zhanyong WeiCollege of Animal Husbandry, Henan Agricultural University, Zhengzhou, Henan 450000, China. weizhanyong@henau.edu.cn.ORCID https://orcid.org/0000-0001-8705-6426
Wenju ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China. Zhangwj1022@sina.com.ORCID https://orcid.org/0000-0002-5314-9904
Anyang Institute of Technology · CNShihezi University · CNHenan Agricultural University · CNHenan Communication Science and Technology Research Institute (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn suckling piglets, transmissible gastroenteritis virus (TGEV) causes lethal diarrhea accompanied by high infection and mortality rates, leading to considerable economic losses. This study explored methods of preventing or inhibiting their production. Bovine antimicrobial peptide-13 (APB-13) has antibacterial, antiviral, and immune functions.

objectivesThis study analyzed the efficacy of APB-13 against TGEV through

methodsThe effects of APB-13 toxicity and virus inhibition rate on swine testicular (ST) cells were detected using 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT). The impact of APB-13 on virus replication was examined through the 50% tissue culture infective dose (TCID

resultsThe safe and effective concentration range of APB-13 on ST cells ranged from 0 to 62.5 μg/mL, and the highest viral inhibitory rate of APB-13 was 74.1%. The log

conclusionsAPB-13 exhibited good antiviral effects on TGEV

Indexed as

AnimalsAntiviral AgentsBlotting, WesternCells, CulturedGastroenteritis, Transmissible, of SwineIntestinesReal-Time Polymerase Chain ReactionSwineTransmissible gastroenteritis virusAntiviral AgentsinfectionsRNA messengerTransmissible gastroenteritis virusviruses

Identifiers

PMID33016025
PMCPMC7533394
OpenAlexW3088704504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.