ArticleKidney medicine
Serum Bicarbonate as a Surrogate for pH in Hemodialysis: A Pilot Study.
Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Concurrent Control of Sodium and Bicarbonate Serum Concentrations Using a Four-Stream Hemodialysis Fluid Delivery System.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Article
- Low serum total COScientific reports · 2021Article
- Intradialytic acid-base changes and organic anion production during high versus low bicarbonate hemodialysis.American journal of physiology. Renal physiology · 2020Article
- Article
- Metabolic Acidosis in CKD: A Review of Recent Findings.Kidney medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
RATIONALE &
objectiveExcess morbidity and mortality are associated with both high and low serum bicarbonate levels in epidemiologic studies of patients with end-stage kidney disease (ESKD) receiving hemodialysis. The Kidney Disease Outcomes Quality Initiative (KDOQI) recommends modifying dialysate bicarbonate concentration to achieve a predialysis serum bicarbonate level ≥ 22 mmol/L, measured as total carbon dioxide (CO STUDY
designPilot study. SETTING &
participants25 veterans with ESKD receiving outpatient hemodialysis. TESTS COMPARED: pH, calculated bicarbonate level, and total CO OUTCOMES: The proportion of paired samples for which total CO
resultsAmong 71 samples, mean pH was 7.41 ± 0.03 predialysis and 7.48 ± 0.05 postdialysis. Compared with interpretation of full blood gas profiles, 9 of 25 (36%) participants were misclassified as acidemic using predialysis total CO LIMITATIONS: Small, single-center, entirely male cohort.
conclusionsA majority of participants became alkalemic during routine hemodialysis despite arriving with normal pH. 10 of 25 (40%) participants' acid-base status was misclassified using total CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.