Evidence map›Paper›PMID 33015377›Full record

ArticleBiochemistry and biophysics reports2020

Dexamethasone does not ameliorate gliosis in a mouse model of neurodegenerative disease.

Xiaolian Ye, Gang Zou, Jinxing Hou, Huiru Bi, Cuihua Zhou, Runmin Wang, Yun Xu, Chun Wang, Guiquan Chen, Zhenyu Yin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xiaolian YeSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Gang ZouSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Jinxing HouSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Huiru BiSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Cuihua ZhouDepartment of Anesthesiology, The Second Affiliated Changzhou People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, China.
Runmin WangSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Yun XuDepartment of Neurology, Jiangsu Provincial Key Medical Discipline, Nanjing Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Avenue, Nanjing, Jiangsu Province, 210008, China.
Chun WangDepartment of Geriatric, Nanjing Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Avenue, Nanjing, Jiangsu Province, 210008, China.
Guiquan ChenSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Zhenyu YinDepartment of Geriatric, Nanjing Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Avenue, Nanjing, Jiangsu Province, 210008, China.
Jinping ZhangDepartment of Medicament, Nanjing Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Avenue, Nanjing, Jiangsu Province, 210008, China.
Chaoli HuangSchool of Medicine, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.
Model Animal Research Center · CNNanjing Drum Tower Hospital · CNChangzhou No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged neuroinflammation is a driving force for neurodegenerative disease, and agents against inflammatory responses are regarded as potential treatment strategies. Here we aimed to evaluate the prevention effects on gliosis by dexamethasone (DEX), an anti-inflammation drug. We used DEX to treat the

Indexed as

DexamethasoneNeurodegenerationNeuroinflammationNeuronSynaptic loss

Identifiers

PMID33015377
PMCPMC7522752
OpenAlexW3088835150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.