ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 33 citations in OpenAlex.
- Clinical Study on the Neuroprotective Effects of Dengzhan Shengmai Capsule on Brain Structure and Cognitive Function in Patients with Vascular Cognitive Impairment.Current Alzheimer research · 2026Trial
- Amyloid-Frontiers in aging neuroscience · 2026Article
- Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.Brain sciences · 2025Article
- Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change.Nature communications · 2025Article
- Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults.Neurobiology of aging · 2025Article
- Sleep quality, APOE ε4, and Alzheimer's disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis.BMC medicine · 2025Article
- Article
- Age-related disturbances in rest-activity rhythms and integrity of the hippocampal network: An exploratory study.Neurobiology of sleep and circadian rhythms · 2025Article
- Stable hippocampal correlates of high episodic memory function across adulthood.Scientific reports · 2025Article
- Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia.Geriatrics (Basel, Switzerland) · 2025Article
- Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life.Nature communications · 2024Article
- Article
- Insights gained over 60 years on factors shaping post-stroke aphasia recovery: A commentary on Vignolo (1964).Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Grey-matter structure in cortical and limbic regions correlates with general cognitive ability in old age.Aging brain · 2024Article
- Aging Brain from a Lifespan Perspective.Current topics in behavioral neurosciences · 2024Review
- No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy.Nature human behaviour · 2023Article
- Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- APOE ɛ4, but not polygenic Alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals.Scientific reports · 2023Article
- Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Opening a conceptual space for metamemory experience.New ideas in psychology · 2023Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 5 countries.
Funding
Abstract
introductionThe apolipoprotein E (
methodsWe analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)-derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European
resultsThe change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, DISCUSSION: These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.