Evidence map›Paper›PMID 33015181›Full record

ArticleBioMed research international2020

Comprehensive Analysis of Differential Immunocyte Infiltration and Potential ceRNA Networks Involved in the Development of Atrial Fibrillation.

Jiafeng Wu, Huiming Deng, Qianghua Chen, Qiang Wu, Xiaolong Li, Siwei Jiang, Fengxin Wang, Fuyin Ye, Langhui Ou, Hong Gao

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jiafeng WuDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Huiming DengDepartment of General Surgery, Zengcheng District People's Hospital of Guangzhou, Guangzhou 511300, China.
Qianghua ChenDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Qiang WuDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Xiaolong LiDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Siwei JiangDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Fengxin WangDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Fuyin YeDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Langhui OuDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.
Hong GaoDepartment of Cardiology, The Third People's Hospital of Shenzhen, Shenzhen 518114, China.ORCID https://orcid.org/0000-0002-2337-8386
Shenzhen Third People’s Hospital · CNGuangdong Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is aimed at identifying potential molecular mechanisms and candidate biomarkers in the left atrial regions for the diagnosis and treatment of valvular atrial fibrillation (VAF). Multibioinformatics methods, including linear models for microarray analysis (LIMMA), an SVA algorithm, CIBERSORT immune infiltration, and DNA methylation analysis, were employed. In addition, the protein-protein interaction (PPI) network, Gene Ontology (GO), and molecular pathways of differentially expressed genes (DEGs) or differential methylation regions were constructed. In all, compared with the normal rhythm group, 243 different mRNAs (29 downregulated and 214 upregulated) and 26 different lncRNAs (3 downregulated and 23 upregulated) were detected in the left atrium (LA) of atrial fibrillation (AF) patients, and the neutrophil and CD8

Indexed as

Gene Regulatory NetworksAtrial FibrillationCD8-Positive T-LymphocytesDNA MethylationGene OntologyHumansRNARNA, Long NoncodingSignal TransductionRNARNA, Long Noncoding

Identifiers

PMID33015181
PMCPMC7525288
OpenAlexW3087311711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.