Evidence map›Paper›PMID 33015088›Full record

ArticleFrontiers in medicine2020

Pancreatic Cancer Malnutrition and Pancreatic Exocrine Insufficiency in the Course of Chemotherapy in Unresectable Pancreatic Cancer.

Mariia Kiriukova, Daniel de la Iglesia Garcia, Nikola Panic, Maryana Bozhychko, Bartu Avci, Patrick Maisonneuve, Enrique de-Madaria, Gabriele Capurso, Vasile Sandru

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Clinical Practice Update on the Evaluation, Diagnosis, and Management of Pancreatic Exocrine Insufficiency: Expert Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Review
  3. Article
  4. Article
  5. Role of noncoding RNAs in pancreatic ductal adenocarcinoma associated cachexia.American journal of physiology. Cell physiology · 2022
    Review
  6. Clinical nutrition as part of the treatment pathway of pancreatic cancer patients: an expert consensus.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 6 countries.

Mariia KiriukovaDepartment of Upper Gastrointestinal, Pancreatic, and Biliary Diseases, Moscow Clinical Scientific Center, Moscow, Russia.
Daniel de la Iglesia GarciaDepartment of Gastroenterology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Nikola PanicDigestive Endoscopy Department, University Clinic "Dr. Dragisa Misovic-Dedinje", Belgrade, Serbia.
Maryana BozhychkoGastroenterology Department, Alicante University General Hospital, ISABIAL, Alicante, Spain.
Bartu AvciIstanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Patrick MaisonneuveUnit of Clinical Epidemiology, Division of Epidemiology and Biostatistics, IEO European Institute of Oncology, IRCCS, Milan, Italy.
Enrique de-MadariaGastroenterology Department, Alicante University General Hospital, ISABIAL, Alicante, Spain.
Gabriele CapursoPancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vasile SandruGastroenterology and Interventional Endoscopy Department, Clinical Emergency Hospital Bucharest, Bucharest, Romania.
Hospital General Universitario de Alicante Doctor Balmis · ESClinical Emergency Hospital Bucharest · ROEuropean Institute of Oncology · ITIstanbul University · TRMoscow Clinical Scientific Center · RUUniversidade de Santiago de Compostela · ESUniversity of Belgrade · RSVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAIN OUTCOME: adherence to planned chemotherapy in the first 12 weeks following the diagnosis, according to patients' baseline nutritional status and quantified and reported as "percent of standard chemotherapy dose delivered." SECONDARY OUTCOMES: rate of chemotherapy-related toxicity, progression-free survival, survival at 6 months, overall survival, quality of life, and the number of hospitalizations. ANALYSIS: chemotherapy dosing over the first 12 weeks of therapy (i.e., percent of chemotherapy received in the first 12 weeks, as defined above) will be compared between well-nourished and malnourished patients. SAMPLE SIZE: based on an expected percentage of chemotherapy delivered of 70% in well-nourished patients, with a type I error of 0.05 and a type II error of 0.20, a sample size of 93 patients per group will be required in case of a percentage difference of chemotherapy delivered of 20% between well-nourished and malnourished patients, 163 patients per group in case of a difference of 15% between the groups, and 356 patients per group in case of a 10% difference. Centers from Russia, Romania, Turkey, Spain, Serbia, and Italy will participate in the study upon Local Ethics Committee approval.

Indexed as

chemotherapydose-intensityexocrine pancreatic insufficiencylocally advancedmetastaticnutritional statuspancreatic cancer

Identifiers

PMID33015088
PMCPMC7509408
OpenAlexW3083463961

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.