ArticleFrontiers in medicine2020
Cognitive Frailty Among Elderly Chinese Patients With Cerebral Small Vessel Disease: A Structural MRI Study.
Article in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Multifactorial analysis of risk factors for frailty and cognitive frailty among hospitalized patients.BMC geriatrics · 2026Article
- Machine learning-based prediction model for cognitive frailty in elderly patients with ischaemic stroke: a prospective cohort study.Frontiers in neurology · 2026Article
- A secondary analysis of cortical atrophy and plasma amyloid β patterns in older patients with cognitive frailty undergoing elective surgery.BMC geriatrics · 2025Article
- Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease.Frontiers in aging neuroscience · 2025Article
- Association of oral frailty and gait characteristics in patients with cerebral small vessel disease.BMC neurology · 2024Article
- Exploring the Multifactorial Landscape: Risk Factors for Dementia in a Tertiary Care Setting in Thailand.Cureus · 2024Article
- Relationship between Body Composition and Gait Characteristics in Patients with Cerebral Small Vessel Disease.Current neurovascular research · 2024Article
- Potential Imaging Biomarkers of Cognitive Frailty.Annals of geriatric medicine and research · 2023Article
- Spatiotemporal gait characteristics during single- and dual-task walking are associated with the burden of cerebral small vessel disease.Frontiers in neurology · 2023Article
- Brain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD).Scientific reports · 2022Article
- Detecting apathy in patients with cerebral small vessel disease.Frontiers in aging neuroscience · 2022Article
- Prevalence and Risk Factors for Cognitive Frailty in Aging Hypertensive Patients in China.Brain sciences · 2021Article
- Associations Between Intellectual and Social Activities With Frailty Among Community-Dwelling Older Adults in China: A Prospective Cohort Study.Frontiers in medicine · 2021Article
- Institutional Residence Protects Against Cognitive Frailty: A Cross-Sectional Study.Inquiry : a journal of medical care organization, provision and financingArticle
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive frailty (CF) is gaining an increasing amount of attention in geriatric research. CF refers to the co-occurrence of physical frailty and cognitive impairment in people without dementia. Neuroimaging of elderly people has revealed the presence of numerous white matter lesions, which is a typical biomarker of cerebral small vessel disease (SVD) on magnetic resonance images. The aim of the present study was to estimate the prevalence of CF in elderly Chinese patients with SVD. One hundred and thirty elderly patients with SVD were recruited for this cross-sectional observational study. Participants who met three to five of the Fried criteria of the physical frailty (PF) phenotype (shrinking, weakness, slowness, self-reported exhaustion, or low physical activity) were classified as having PF. Then, individuals with PF were defined as having CF if mild cognitive impairment was discovered by the Mini-Mental State Examination. Lastly, a series of cognitive function tests and the dual-task walking paradigm were examined. Based on the CF diagnostic criteria, the frequency of CF was 23.08% among elderly Chinese patients with SVD. Furthermore, CF-positive patients had a more significant SVD burden, based on magnetic resonance imaging findings. Logistic regression analysis, which was adjusted for age, sex, education, and comorbidities, showed that CF was negatively correlated with the dual-task walking speed in elderly people with SVD. Thus, SVD burden might be an indicator of CF phenotype. In elderly patients with SVD, CF was associated with dual task walking performance.
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