Evidence map›Paper›PMID 33015071›Full record

ArticleFrontiers in cell and developmental biology2020

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival.

Abhiraami Kannan-Sundhari, Clemer Abad, Marie E Maloof, Nagi G Ayad, Juan I Young, Xue Zhong Liu, Katherina Walz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. An interplay between BRD4 and G9a regulates skeletal myogenesis.Frontiers in cell and developmental biology · 2022
    Article
  4. Brd4 Regulates the Homeostasis of CD8Frontiers in immunology · 2021
    Article
  5. Frontiers in neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Abhiraami Kannan-SundhariDepartment of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Clemer AbadJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, United States.
Marie E MaloofThe Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Nagi G AyadThe Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Juan I YoungThe Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, United States.
Xue Zhong LiuDepartment of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Katherina WalzThe Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, United States.
Dr. John T. Macdonald Foundation · USNeurological Surgery · USUniversity of Miami · US

Funding

Epigenetic pathways and cell cycle exitR01NS118023 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AYAD, NAGI G · 2020 to 2024
$1.8M
NINDS NIH HHS R01 NS118023
6 · The paper itself

Abstract

Hair cells (HCs) play crucial roles in perceiving sound, acceleration, and fluid motion. The tonotopic architecture of the sensory epithelium recognizes mechanical stimuli and convert them into electrical signals. The expression and regulation of the genes in the inner ear is very important to keep the sensory organ functional. Our study is the first to investigate the role of the epigenetic reader

Indexed as

Brd4functionhair cell losshair cellshearing losssurvival

Identifiers

PMID33015071
PMCPMC7509448
OpenAlexW3083816054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.