Evidence map›Paper›PMID 33014890›Full record

ArticleFrontiers in cellular and infection microbiology2020

Host Porphobilinogen Deaminase Deficiency Confers Malaria Resistance in

Cilly Bernardette Schnider, Hao Yang, Lora Starrs, Anna Ehmann, Farid Rahimi, Elena Di Pierro, Giovanna Graziadei, Kathryn Matthews, Tania De Koning-Ward, Denis C Bauer and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022
    Review
  4. Host Porphobilinogen Deaminase Deficiency Confers Malaria Resistance inFrontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Cilly Bernardette SchniderDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Hao YangDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Lora StarrsDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Anna EhmannDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Farid RahimiResearch School of Biology, The Australian National University, Canberra, ACT, Australia.
Elena Di PierroFondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Internal Medicine Unit, Department of Medicine and Medical Specialties, Rare Diseases Center, Milan, Italy.
Giovanna GraziadeiFondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Internal Medicine Unit, Department of Medicine and Medical Specialties, Rare Diseases Center, Milan, Italy.
Kathryn MatthewsSchool of Medicine, Deakin University, Geelong, VIC, Australia.
Tania De Koning-WardSchool of Medicine, Deakin University, Geelong, VIC, Australia.
Denis C BauerHealth and Biosecurity, CSIRO, Sydney, NSW, Australia.
Simon J FooteDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Gaetan BurgioDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Brendan J McMorranDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Australian National University · AUDeakin University · AUFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITCSIRO Health and Biosecurity · AUMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment strategies. A mouse ENU-induced mutagenesis screen for novel malaria resistance-conferring mutations identified a novel non-sense mutation in the gene encoding porphobilinogen deaminase (PBGD) in mice, denoted here as

Indexed as

MalariaPlasmodium chabaudiPorphyria, Acute IntermittentAnimalsErythrocytesHumansMicePlasmodium bergheiPlasmodium falciparumhost resistanceintraerythrocytic growthmalariaPlasmodiumporphobilinogen [deaminase]

Identifiers

PMID33014890
PMCPMC7495142
OpenAlexW3082325823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.