Evidence map›Paper›PMID 33014615›Full record

ArticleBiomedical optics express2020

Semi-automated shear stress measurements in developing embryonic hearts.

Sahar Elahi, Brecken J Blackburn, Maryse Lapierre-Landry, Shi Gu, Andrew M Rollins, Michael W Jenkins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sahar ElahiDepartment of Pediatrics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Brecken J BlackburnDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Maryse Lapierre-LandryDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.ORCID https://orcid.org/0000-0002-9583-6876
Shi GuDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Andrew M RollinsDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Michael W JenkinsDepartment of Pediatrics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Case Western Reserve University · US

Funding

Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart DefectsR01HL126747 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JENKINS, MICHAEL W. · 2015 to 2025
$6.4M
OCT Imaging Technology for Developmental Cardiology ResearchR01HL083048 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ROLLINS, ANDREW MARTIN · 2006 to 2016
$3.2M
Noninvasive assessment of the cornea by diffusion OCTR01EY028667 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI DUPPS, WILLIAM JOSEPH, ROLLINS, ANDREW MARTIN · 2018 to 2022
$2.0M
NEI NIH HHS R01 EY028667NHLBI NIH HHS R01 HL083048NHLBI NIH HHS R01 HL126747
6 · The paper itself

Abstract

Blood-induced shear stress influences gene expression. Abnormal shear stress patterns on the endocardium of the early-stage heart tube can lead to congenital heart defects. To have a better understanding of these mechanisms, it is essential to include shear stress measurements in longitudinal cohort studies of cardiac development. Previously reported approaches are computationally expensive and nonpractical when assessing many animals. Here, we introduce a new approach to estimate shear stress that does not rely on recording 4D image sets and extensive post processing. Our method uses two adjacent optical coherence tomography frames (B-scans) where lumen geometry and flow direction are determined from the structural data and the velocity is measured from the Doppler OCT signal. We validated our shear stress estimate by flow phantom experiments and applied it to live quail embryo hearts where observed shear stress patterns were similar to previous studies.

Identifiers

PMID33014615
PMCPMC7510878
OpenAlexW3021878112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.