ArticleBiomedical optics express2020
FLImBrush: dynamic visualization of intraoperative free-hand fiber-based fluorescence lifetime imaging.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Flexible intraoperative detectors for robotic and laparoscopic image-guided surgery: a systematic review.European journal of nuclear medicine and molecular imaging · 2026Pooled it
- Intraoperative Mapping of Parathyroid Glands Using Fluorescence Lifetime Imaging.The Journal of surgical research · 2021Trial
- Development of solid-state fluorescence lifetime standards for clinical applications using dyed epoxy resins.Journal of biomedical optics · 2026Article
- Considerations for transoral robotic surgery with fluorescence imaging: a narrative review.Journal of robotic surgery · 2026Review
- Article
- Hidden in visible light: spectral-temporal unmixing of lung tissue autofluorescence in a fibre-based system.Biomedical optics express · 2026Article
- Qualitative and quantitative assessment ofBiomedical optics express · 2026Article
- Phasor theory of fluorescence lifetime imaging utilized on a maximum range of frequencies for prostate tissue analysis.Biomedical optics express · 2025Article
- Data-Centric Learning Framework for Real-Time Detection of Aiming Beam in Fluorescence Lifetime Imaging Guided Surgery.IEEE transactions on bio-medical engineering · 2025Article
- A low-cost FPGA-based approach for pile-up corrected high-speedNeurophotonics · 2025Article
- Label-free optical microscopy with artificial intelligence: a new paradigm in pathology.Biophotonics discovery · 2025Review
- Multispectral laser-scanning pulse-sampling fluorescence lifetime system for large-scale tissue imaging.Optics letters · 2025Article
- Perspective on the use of fluorescence molecular imaging for peripheral and deepJournal of biomedical optics · 2025Review
- Early Detection of Lymph Node Metastasis Using Primary Head and Neck Cancer Computed Tomography and Fluorescence Lifetime Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- Fibre-based fluorescence-lifetime imaging microscopy: a real-time biopsy guidance tool for suspected lung cancer.Translational lung cancer research · 2024Article
- Fibre-optic based exploration of lung cancer autofluorescence using spectral fluorescence lifetime.Biomedical optics express · 2024Article
- Combined fluorescence lifetime and surface topographical imaging of biological tissue.Biomedical optics express · 2024Article
- Anatomy-Specific Classification Model Using Label-Free FLIm to Aid Intraoperative Surgical Guidance of Head and Neck Cancer.IEEE transactions on bio-medical engineering · 2023Article
- In vivo characterization of the human glioblastoma infiltrative edge with label-free intraoperative fluorescence lifetime imaging.Biomedical optics express · 2023Article
- Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report.Head & neck · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
A free-hand scanning approach to medical imaging allows for flexible, lightweight probes to image intricate anatomies for modalities such as fluorescence lifetime imaging (FLIm), optical coherence tomography (OCT) and ultrasound. While very promising, this approach faces several key challenges including tissue motion during imaging, varying lighting conditions in the surgical field, and sparse sampling of the tissue surface. These challenges limit the coregistration accuracy and interpretability of the acquired imaging data. Here we report FLImBrush as a robust method for the localization and visualization of intraoperative free-hand fiber optic fluorescence lifetime imaging (FLIm). FLImBrush builds upon an existing method while employing deep learning-based image segmentation, block-matching based motion correction, and interpolation-based visualization to address the aforementioned challenges. Current results demonstrate that FLImBrush can provide accurate localization of FLIm point-measurements while producing interpretable and complete visualizations of FLIm data acquired from a tissue surface. Each of the main processing steps was shown to be capable of real-time processing (> 30 frames per second), highlighting the feasibility of FLImBrush for intraoperative imaging and surgical guidance. Current findings show the feasibility of integrating FLImBrush into a range of surgical applications including cancer margins assessment during head and neck surgery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.