Evidence map›Paper›PMID 33014584›Full record

ArticleBiomedical optics express2020

Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina.

Weiye Song, Wenjun Shao, Wei Yi, Rongrong Liu, Manishi Desai, Steven Ness, Ji Yi

Abstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Frontiers in ophthalmology · 2025
    Review
  13. Quantitative Optical Imaging of Oxygen in Brain Vasculature.The journal of physical chemistry. B · 2024
    Review
  14. Article
  15. Targeted spectroscopy in the eye fundus.Journal of biomedical optics · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weiye SongDepartment of Medicine, Boston University School of Medicine, Boston Medical Center, Boston 02118, USA.ORCID https://orcid.org/0000-0002-1835-9770
Wenjun ShaoDepartment of Medicine, Boston University School of Medicine, Boston Medical Center, Boston 02118, USA.
Wei YiDepartment of Medicine, Boston University School of Medicine, Boston Medical Center, Boston 02118, USA.
Rongrong LiuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Manishi DesaiDepartment of Ophthalmology, Boston University School of Medicine, Boston Medical Center, Boston 02118, USA.
Steven NessDepartment of Ophthalmology, Boston University School of Medicine, Boston Medical Center, Boston 02118, USA.
Ji YiDepartment of Medicine, Boston University School of Medicine, Boston Medical Center, Boston 02118, USA.ORCID https://orcid.org/0000-0001-6583-7192

Funding

Predictive markers for diabetic retinopathy via quantitative imaging of retinal capillary functionsR01NS108464 · NINDS · JOHNS HOPKINS UNIVERSITY · PI YI, JI · 2018 to 2022
$2.5M
Nanodelivery platform for antibody drugs targeting NHLR01CA232015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAMATA, MASAKAZU · 2018 to 2022
$2.5M
Sensitive detection of malignancy in primary acquired melanosis by advanced optical imagingR21EY029412 · NEI · JOHNS HOPKINS UNIVERSITY · PI LEE, HYUNJOO JEAN, YI, JI · 2018 to 2019
$456k
NCI NIH HHS R01 CA232015NEI NIH HHS R21 EY029412NINDS NIH HHS R01 NS108464
6 · The paper itself

Abstract

We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the imaging protocol such that a single acquisition took < 6 seconds with a field of view (FOV) of 3×7.8 mm

Identifiers

PMID33014584
PMCPMC7510897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.