ArticleBiomedical optics express2020
Sensorless adaptive-optics optical coherence tomographic angiography.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Coefficient-metric gradient-based digital wavefront correction for full-field swept-source optical coherence tomography.Biomedical optics express · 2026Article
- Deep reinforcement learning for automatic defocus correction using OCT image intensity.Biomedical optics express · 2025Article
- Dual acquisition scheme-based optical coherence tomography 3D angiography.Journal of biomedical optics · 2025Article
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- Image metric-based multi-observation single-step deep deterministic policy gradient for sensorless adaptive optics.Biomedical optics express · 2024Article
- Multifunctional adaptive optics optical coherence tomography allows cellular scale reflectometry, polarimetry, and angiography in the living human eye.Biomedical optics express · 2024Article
- Twenty-five years of clinical applications using adaptive optics ophthalmoscopy [Invited].Biomedical optics express · 2023Review
- Computational adaptive holographic fluorescence microscopy based on the stochastic parallel gradient descent algorithm.Biomedical optics express · 2022Article
- Volumetric directional optical coherence tomography.Biomedical optics express · 2022Article
- Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography.Biomedical optics express · 2021Article
- A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021Article
- Developing a normative database for retinal perfusion using optical coherence tomography angiography.Biomedical optics express · 2021Article
- High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source.Biomedical optics express · 2021Article
- Adaptive optics: principles and applications in ophthalmology.Eye (London, England) · 2021Review
- Advances in multimodal imaging in ophthalmology.Therapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with clinical relevance. In this manuscript, we developed a sensorless AO-OCTA prototype with an intermediate numerical aperture to produce depth-resolved angiograms with high resolution and signal-to-noise ratio over a 2 × 2 mm FOV, with a focal spot diameter of 6 µm, which is about 3 times finer than typical commercial OCT systems. We believe these parameters may represent a better tradeoff between resolution and FOV compared to large-NA AO systems, since the spot size matches better that of capillaries. The prototype corrects defocus, astigmatism, and coma using a figure of merit based on the mean reflectance projection of a slab defined with real-time segmentation of retinal layers. AO correction with the ability to optimize focusing in arbitrary retinal depths - particularly the plexuses in the inner retina - could be achieved in 1.35 seconds. The AO-OCTA images showed greater flow signal, signal-to-noise ratio, and finer capillary caliber compared to commercial OCTA. Projection artifacts were also reduced in the intermediate and deep capillary plexuses. The instrument reported here improves OCTA image quality without excessive sacrifice in FOV and device complexity, and thus may have potential for clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.