Evidence map›Paper›PMID 33014553›Full record

ArticleBiomedical optics express2020

Reconstruction of high-resolution 6×6-mm OCT angiograms using deep learning.

Min Gao, Yukun Guo, Tristan T Hormel, Jiande Sun, Thomas S Hwang, Yali Jia

Abstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Widefield OCT angiography.Progress in retinal and eye research · 2025
    Review
  8. Article
  9. Article
  10. Nonperfused Retinal Capillaries-A New Method Developed on OCT and OCTA.Investigative ophthalmology & visual science · 2025
    Article
  11. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Advances in multimodal imaging for diagnosis of pigmented ocular fundus lesions.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min GaoCasey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0002-0344-0162
Yukun GuoCasey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0002-6784-2355
Tristan T HormelCasey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Jiande SunSchool of Information Science and Engineering, Shandong Normal University, Jinan 250358, China.
Thomas S HwangCasey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Yali JiaCasey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0002-2784-1905

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NEI NIH HHS T32 EY023211
6 · The paper itself

Abstract

Typical optical coherence tomographic angiography (OCTA) acquisition areas on commercial devices are 3×3- or 6×6-mm. Compared to 3×3-mm angiograms with proper sampling density, 6×6-mm angiograms have significantly lower scan quality, with reduced signal-to-noise ratio and worse shadow artifacts due to undersampling. Here, we propose a deep-learning-based high-resolution angiogram reconstruction network (HARNet) to generate enhanced 6×6-mm superficial vascular complex (SVC) angiograms. The network was trained on data from 3×3-mm and 6×6-mm angiograms from the same eyes. The reconstructed 6×6-mm angiograms have significantly lower noise intensity, stronger contrast and better vascular connectivity than the original images. The algorithm did not generate false flow signal at the noise level presented by the original angiograms. The image enhancement produced by our algorithm may improve biomarker measurements and qualitative clinical assessment of 6×6-mm OCTA.

Identifiers

PMID33014553
PMCPMC7510902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.