Deep OCT image compression with convolutional neural networks.

We report an end-to-end image compression framework for retina optical coherence tomography (OCT) images based on convolutional neural networks (CNNs), which achieved an image size compression ratio as high as 80. Our compression scheme consists of three parts: data preprocessing, compression CNNs, and reconstruction CNNs. The preprocessing module was designed to reduce OCT speckle noise and segment out the region of interest. Skip connections with quantization were developed and added between the compression CNNs and the reconstruction CNNs to reserve the fine-structure information. Two networks were trained together by taking the semantic segmented images from the preprocessing module as input. To train the two networks sensitive to both low and high frequency information, we leveraged an objective function with two components: an adversarial discriminator to judge the high frequency information and a differentiable multi-scale structural similarity (MS-SSIM) penalty to evaluate the low frequency information. The proposed framework was trained and evaluated on ophthalmic OCT images with pathological information. The evaluation showed reconstructed images can still achieve above 99% similarity in terms of MS-SSIM when the compression ratio reached 40. Furthermore, the reconstructed images after 80-fold compression with the proposed framework even presented comparable quality with those of a compression ratio 20 from state-of-the-art methods. The test results showed that the proposed framework outperformed other methods in terms of both MS-SSIM and visualization, which was more obvious at higher compression ratios. Compression and reconstruction were fast and took only about 0.015 seconds per image. The results suggested a promising potential of deep neural networks on customized medical image compression, particularly valuable for effective image storage and tele-transfer.