ArticleJournal of translational science2020
Obstructive sleep apnea in obese minipigs.
Article in Journal of translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Spatial relationships of oropharyngeal structures during respiration, chewing, and swallowing.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig.PloS one · 2023Article
- Article
- Pharyngeal airway dimensions and adipose distribution in the minipig.Journal of oral biology and craniofacial researchArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveObesity has reached epidemic proportions and is a strong risk factor for obstructive sleep apnea (OSA). However, the underlying mechanisms are poorly understood and current treatment strategies for OSA and obesity have critical limitations. Thus, establishment of an obesity-related large animal model with spontaneous OSA is imperative. MATERIALS AND
methodsNatural and sedated sleep were monitored and characterized in 4 obese (body mass index - BMI>48) and 3 non-obese (BMI<40) minipigs. These minipigs were instrumented with the BioRadio system under sedation for the wireless recording of respiratory airflow, snoring, abdominal and chest respiratory movements, electroencephalogram, electrooclulogram, electromyogram, and oxygen saturation. After instrumentation, the minipigs were placed in a dark room with a remote night-vision camera for monitoring all behaviors. Wakefulness and different sleep stages were classified, and episodes of apneas and/or hypopneas were identified during natural and/or sedated sleep.
resultsNo hypopnea episodes were observed in two of the non-obese minipigs, but one non-obese minipig had 5 hypopnea events. Heavy snoring and 27-58 apnea and/or hypopnea episodes were identified in all 4 obese minipigs. Most of these episodes occurred in the rapid eye movement stage during natural sleep and/or sedated sleep in Yucatan minipigs.
conclusionsObese minipigs can experience naturally occurring OSA, thus are an ideal large animal model for obese-related OSA studies.
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Registered trials
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