Evidence map›Paper›PMID 33014268›Full record

ArticleOxidative medicine and cellular longevity2020

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2

Pol Picón-Pagès, Daniela A Gutiérrez, Alejandro Barranco-Almohalla, Giulia Crepin, Marta Tajes, Gerard Ill-Raga, Francesc X Guix, Silvia Menéndez, Montserrat Arumí-Uría, Rubén Vicente and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  8. ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Pol Picón-PagèsLaboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Daniela A GutiérrezCell Signaling Laboratory, Centro UC de Envejecimiento y Regeneración (CARE), Department of Cellular and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago, Chile.
Alejandro Barranco-AlmohallaLaboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Giulia CrepinLaboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Marta TajesGroup of Biomedical Research in Heart Diseases, Hospital del Mar-Medical Research Institute (IMIM), Barcelona, Spain.
Gerard Ill-RagaDivision of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Francesc X GuixDepartment of Molecular Neurobiology, Centro de Biología Molecular "Severo Ochoa", CSIC-UAM, Madrid, Spain.
Silvia MenéndezCancer Research Programm, Hospital del Mar-Medical Research Institute (IMIM), Parc de Salut Mar, Barcelona, Spain.
Montserrat Arumí-UríaServicio de Anatomía Patológica, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
Rubén VicenteLaboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Alejandra R ÁlvarezCell Signaling Laboratory, Centro UC de Envejecimiento y Regeneración (CARE), Department of Cellular and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago, Chile.
Francisco J MuñozLaboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0000-0002-1343-3599
Universitat Pompeu Fabra · ESParc de Salut · ESPontificia Universidad Católica de Chile · CLCentro de Biología Molecular Severo Ochoa · ESHospital Del Mar · ESUniversidade Federal do Espírito Santo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (A

Indexed as

5' Untranslated RegionsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesCell Line, TumorCell SurvivalEukaryotic Initiation Factor-2HippocampusHumansHydrogen PeroxideOxidative StressPhosphorylationUp-Regulation5' Untranslated RegionsAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesEukaryotic Initiation Factor-2Hydrogen Peroxide

Identifiers

PMID33014268
PMCPMC7525306
OpenAlexW3088775157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.