Evidence map›Paper›PMID 33014091›Full record

ReviewKardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery2020

A modified heterotopic heart transplantation in the rat - as an important model in experimental regeneration and replacement of the failing organ.

Joanna E Śliwka, Mirosław Tyrpień, Piotr M Wilczek, Marian Zembala, Piotr Przybyłowski

Abstract readReview
In one paragraph

Review in Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joanna E ŚliwkaDepartment of Cardiac Surgery, Transplantology and Mechanical Circulatory Support in Children, Silesian Center for Heart Diseases, Zabrze, Poland.
Mirosław TyrpieńDepartment of Environmental Medicine and Epidemiology, Medical University of Silesia, Zabrze, Poland.
Piotr M WilczekFoundation for Cardiac Surgery Development, Zabrze, Poland.
Marian ZembalaDepartment of Cardiac Surgery, Transplantology and Vascular Surgery, Medical University of Silesia, Zabrze, Poland.
Piotr PrzybyłowskiFirst Chair of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The qualification of new knowledge is one of the oldest problems in experimental medicine that provides a link between fundamental discovery, hypothesis, 'proof of concept' preclinical studies and development of clinical trials. The biggest challenge in animal models is the proper evaluation of all the aspects that are crucial in specific studied pathologies as well as the prediction of their progression. The aim of this review was to describe and discuss the rat animal model of heart transplant. The rat model of heart transplantation is an excellent yet underestimated method of research of prevention, monitoring and treatment of acute and chronic, immune and nonimmune response to organ transplantation. Despite being a technically and logistically demanding model, it provides a tool for reproducible experiments with longterm animal survival and excellent graft survival.

Indexed as

animal modelheart transplantationsex differences

Identifiers

PMID33014091
PMCPMC7526486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.