ArticleNeural plasticity2020
The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid
Article in Neural plasticity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Retinal biomarkers for early Alzheimer's detection: a systematic review of optical coherence tomography (OCT) findings.BMJ open ophthalmology · 2026Pooled it
- Association between retinal markers and cognition in older adults: a systematic review.BMJ open · 2022Pooled it
- Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model.Pharmaceutics · 2023Article
- Hemispheric Patterns of Recruitment of Object Processing Regions in Early Alzheimer's Disease: A Study Along the Entire Ventral Stream.Journal of Alzheimer's disease : JAD · 2023Article
- Correlation between retinal structure and brain multimodal magnetic resonance imaging in patients with Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Textural properties of microglial activation in Alzheimer's disease as measured by (R)-[Brain communications · 2023Article
- Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.Eye and brain · 2023Article
- Article
- Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina.Molecules (Basel, Switzerland) · 2021Article
- Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Retinal manifestations and their diagnostic significance in Alzheimer's disease.Journal of Alzheimer's disease reportsReview
- Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Multiscale Analysis of Alzheimer's Disease Using Feature Fusion in Cognitive and Sensory Brain Regions.Digital biomarkersArticle
- Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta-analysis of studies using brain amyloid beta status for case definition.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer's disease (AD). Here, we investigated synapse-rich layers versus layers composed by nuclei/cell bodies in an early stage of AD. In addition, we examined the associations between retinal changes and molecular and structural markers of cortical damage. We recruited 20 AD patients and 17 healthy controls (HC). Combining optical coherence tomography (OCT), magnetic resonance (MR), and positron emission tomography (PET) imaging, we measured retinal and primary visual cortex (V1) thicknesses, along with V1 amyloid
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.