Evidence map›Paper›PMID 33014022›Full record

ArticleFrontiers in genetics2020

Variation rs2235503 C > A Within the Promoter of

Roberto Silvestri, Perla Pucci, Chiara De Santi, Irene Dell'Anno, Simona Miglietta, Alda Corrado, Vanessa Nicolí, Daniela Marolda, Monica Cipollini, Enrica Pellegrino and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Roberto SilvestriDepartment of Biology, University of Pisa, Pisa, Italy.
Perla PucciDepartment of Biology, University of Pisa, Pisa, Italy.
Chiara De SantiDepartment of Biology, University of Pisa, Pisa, Italy.
Irene Dell'AnnoDepartment of Biology, University of Pisa, Pisa, Italy.
Simona MigliettaDepartment of Biology, University of Pisa, Pisa, Italy.
Alda CorradoDepartment of Biology, University of Pisa, Pisa, Italy.
Vanessa NicolíDepartment of Biology, University of Pisa, Pisa, Italy.
Daniela MaroldaDepartment of Biology, University of Pisa, Pisa, Italy.
Monica CipolliniDepartment of Biology, University of Pisa, Pisa, Italy.
Enrica PellegrinoDepartment of Biology, University of Pisa, Pisa, Italy.
Monica EvangelistaInstitute of Clinical Physiology (IFC), CNR, Pisa, Italy.
Alessandra BonottiPreventive and Occupational Medicine, University Hospital of Pisa, Pisa, Italy.
Rudy FoddisDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Alfonso CristaudoDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Stefano LandiDepartment of Biology, University of Pisa, Pisa, Italy.
Federica GemignaniDepartment of Biology, University of Pisa, Pisa, Italy.
University of Pisa · ITAzienda Ospedaliera Universitaria Pisana · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto di Fisiologia Clinica · ITUniversity of Cambridge · GBUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble mesothelin-related peptide (SMRP) is a promising biomarker for malignant pleural mesothelioma (MPM), but several confounding factors can reduce SMRP-based test's accuracy. The identification of these confounders could improve the diagnostic performance of SMRP. In this study, we evaluated the sequence of 1,000 base pairs encompassing the minimal promoter region of the

Indexed as

diagnostic biomarkerseQTLfluorescent reporter assaymalignant pleural mesotheliomasingle nucleotide polymorphismssoluble mesothelin-related peptide

Identifiers

PMID33014022
PMCPMC7461867
OpenAlexW3052846595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.