Evidence map›Paper›PMID 33013934›Full record

ArticleFrontiers in immunology2020

CD4

Zhisheng Her, Joel Heng Loong Tan, Yee-Siang Lim, Sue Yee Tan, Xue Ying Chan, Wilson Wei Sheng Tan, Min Liu, Kylie Su Mei Yong, Fritz Lai, Erica Ceccarello and 13 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. The Cardiohepatic Axis in Metabolic Disease: Liver to Heart.JACC. Basic to translational science · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. The Role of CD4International journal of molecular sciences · 2024
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 2 countries.

Zhisheng HerInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Joel Heng Loong TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Yee-Siang LimGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Sue Yee TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Xue Ying ChanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Wilson Wei Sheng TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Min LiuInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Kylie Su Mei YongInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Fritz LaiInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Erica CeccarelloInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Zhiqiang ZhengInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Yong FanKey Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kenneth Tou En ChangDepartment of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
Lei SunCardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore.
Shih Chieh ChangLaboratory of Molecular Physiology, Infection and Immunity Theme, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Chih-Liang ChinTranslational Biomarkers, Merck Research Laboratories, MSD, Singapore, Singapore.
Guan Huei LeeDivision of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore, Singapore.
Yock Young DanDivision of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore, Singapore.
Yun-Shen ChanGenome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Seng Gee LimDivision of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore, Singapore.
Jerry Kok Yen ChanDepartment of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
K George ChandyLaboratory of Molecular Physiology, Infection and Immunity Theme, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Qingfeng ChenInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Agency for Science, Technology and Research · SGInstitute of Molecular and Cell Biology · SGDuke-NUS Medical School · SGNanyang Technological University · SGNational University Hospital · SGNational University of Singapore · SGGuangzhou Medical University · CNKK Women's and Children's Hospital · SGMerck (Singapore) · SGNational University Health System · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chronic inflammation, and CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCytokinesDiet, High-FatFemaleFetal Stem CellsHepatocytesHeterograftsHumansInterleukin Receptor Common gamma SubunitLiver Cirrhosis, ExperimentalLymphocyte DepletionMaleMiceMice, Inbred NODMice, KnockoutCytokinesIl2rg protein, mouseInterleukin Receptor Common gamma SubunitCD4+ T cellshumanized mouse modelliver fibrosisNAFLDNASH

Identifiers

PMID33013934
PMCPMC7516019
OpenAlexW3085537009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.