Evidence map›Paper›PMID 33013901›Full record

ArticleFrontiers in immunology2020

Non-human Primate Determinants of Natural Killer Cells in Tissues at Steady-State and During Simian Immunodeficiency Virus Infection.

Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Jean-Louis Palgen, Christiane Stahl-Hennig, Roger Le Grand, Anne-Sophie Beignon, Beatrice Jacquelin, Michaela Müller-Trutwin

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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  4. Review
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  12. Role of NKG2a/ciScience · 2021
    Article
  13. Article
  14. CD32Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Nicolas HuotUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris, France.
Philippe RascleUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris, France.
Caroline PetitdemangeUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris, France.
Vanessa ContrerasCEA-Université Paris Saclay-Inserm, U1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases, IMVA-HB/IDMIT, Fontenay-aux-Roses, France.
Jean-Louis PalgenCEA-Université Paris Saclay-Inserm, U1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases, IMVA-HB/IDMIT, Fontenay-aux-Roses, France.
Christiane Stahl-HennigDeutsches Primatenzentrum, Göttingen, Germany.
Roger Le GrandCEA-Université Paris Saclay-Inserm, U1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases, IMVA-HB/IDMIT, Fontenay-aux-Roses, France.
Anne-Sophie BeignonCEA-Université Paris Saclay-Inserm, U1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases, IMVA-HB/IDMIT, Fontenay-aux-Roses, France.
Beatrice JacquelinUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris, France.
Michaela Müller-TrutwinUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris, France.
Institut Pasteur · FRCEA Paris-Saclay · FRUniversité Paris-Saclay · FRGerman Primate Center · DESorbonne Paris Cité · FR

Funding

Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid FolliclesR01AI143457 · NIAID · DUKE UNIVERSITY · PI REEVES, ROGER KEITH · 2019 to 2023
$3.1M
NIAID NIH HHS R01 AI143457
6 · The paper itself

Abstract

Natural killer (NK) cells play essential roles in immunity to viruses and tumors. Their function is genetically determined but also modulated by environmental factors. The distribution and functional regulation of these cells vary depending on the tissue. NK cell behavior in lymphoid tissues is so far understudied. Non-human primate (NHP) models are essential for the development of therapies and vaccines against human diseases, and access to NHP tissues allows insights into spatial regulations of NK cells. Here, we investigated tissue-specific parameters of NK cells from NHP species, i.e., cynomolgus macaque (

Indexed as

Acquired Immunodeficiency SyndromeAnimalsCells, CulturedHIV-1HIV InfectionsHumansImmunophenotypingKiller Cells, NaturalLymphoid TissueNatural Cytotoxicity Triggering Receptor 2Organ SpecificityPrimatesReceptors, CXCR5Simian Immunodeficiency VirusSpecies SpecificityCXCR5 protein, humanNatural Cytotoxicity Triggering Receptor 2NCR2 protein, humanReceptors, CXCR5CXCR5gutHIVlymph nodeNK cellsNKp44SIVtissue resident

Identifiers

PMID33013901
PMCPMC7511519
OpenAlexW3085726321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.