ArticleFrontiers in microbiology2020
Dysbiosis in the Dead: Human Postmortem Microbiome Beta-Dispersion as an Indicator of Manner and Cause of Death.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Microbiome modelling for post-mortem interval estimation across species and climates: swine analogues in a British summer and external validation in human donors from the USA.Scientific reports · 2026Article
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- DNA forensics at forty: the way forward.International journal of legal medicine · 2025Review
- The Latest Advances in Omics Technology for Assessing Tissue Damage: Implications for the Study of Sudden Cardiac Death.International journal of molecular sciences · 2025Review
- Impact ofJournal of clinical medicine · 2024Review
- Article
- Human microbiome transfer in the built environment differs based on occupants, objects, and buildings.Scientific reports · 2023Article
- Feature selection with a genetic algorithm can help improve the distinguishing power of microbiota information in monozygotic twins' identification.Frontiers in microbiology · 2023Article
- Trends in forensic microbiology: From classical methods to deep learning.Frontiers in microbiology · 2023Review
- COVID-19 and brain-heart-lung microbial fingerprints in Italian cadavers.Frontiers in molecular biosciences · 2023Article
- Postmortem skin microbiome signatures associated with human cadavers within the first 12 h at the morgue.Frontiers in microbiology · 2023Article
- Review
- The devil is in the details: Variable impacts of season, BMI, sampling site temperature, and presence of insects on the post-mortem microbiome.Frontiers in microbiology · 2022Article
- Cronos: A Machine Learning Pipeline for Description and Predictive Modeling of Microbial Communities Over Time.Frontiers in bioinformatics · 2022Article
- Characterization of Bacterial Community Dynamics of the Human Mouth Throughout DecompositionFrontiers in microbiology · 2021Article
- At the Interface of Life and Death: Post-mortem and Other Applications of Vaginal, Skin, and Salivary Microbiome Analysis in Forensics.Frontiers in microbiology · 2021Review
- Effects of Extended Postmortem Interval on Microbial Communities in Organs of the Human Cadaver.Frontiers in microbiology · 2020Article
- Forensic Applications of Microbiomics: A Review.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The postmortem microbiome plays an important functional role in host decomposition after death. Postmortem microbiome community successional patterns are specific to body site, with a significant shift in composition 48 h after death. While the postmortem microbiome has important forensic applications for postmortem interval estimation, it also has the potential to aid in manner of death (MOD) and cause of death (COD) determination as a reflection of antemortem health status. To further explore this association, we tested beta-dispersion, or the variability of microbiomes within the context of the "Anna Karenina Principle" (AKP). The foundational principle of AKP is that stressors affect microbiomes in unpredictable ways, which increases community beta-dispersion. We hypothesized that cases with identified M/CODs would have differential community beta-dispersion that reflected antemortem conditions, specifically that cardiovascular disease and/or natural deaths would have higher beta-dispersion compared to other deaths (e.g., accidents, drug-related deaths). Using a published microbiome data set of 188 postmortem cases (five body sites per case) collected during routine autopsy in Wayne County (Detroit), MI, we modeled beta-dispersion to test for M/COD associations
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