ReviewFrontiers in endocrinology2020
The "IAG-Switch"-A Key Controlling Element in Decapod Crustacean Sex Differentiation.
Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 77 citations in OpenAlex.
- Dietary arginine modulates growth performance and testicular development across life stages in male swimming crab (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of RNA Interference-Mediated Silencing of the Insulin-Like Androgenic Gland Hormone Gene on Growth and Gonad Development in the Swimming Crab (Animals : an open access journal from MDPI · 2026Article
- Reduction of body segmentation in the skeleton shrimp Caprella scaura (Amphipoda: Caprellidae) inferred from comparative internal anatomy of Caprelloidea.Die Naturwissenschaften · 2026Article
- Identification and Validation of Tissue-Specific Housekeeping Markers for the Amazon River PrawnGenes · 2025Article
- The Effects of Eyestalk Ablation on the Androgenic Gland and the Male Reproductive Organs in the Kuruma PrawnAnimals : an open access journal from MDPI · 2025Article
- Full-Length Transcriptome of Testis and Ovary Provides Insights into Alternative Splicing During Gonadal Development inInternational journal of molecular sciences · 2025Article
- Roles of a Y-Linked iDmrt1 Paralogue and Insulin-like Androgenic Gland Hormone in Sexual Development in the Tropical Rock Lobster,International journal of molecular sciences · 2025Article
- Article
- Involvement of the ovarian-specific Mro-IR in oogonia differentiation and oocyte development in freshwater giant prawnFrontiers in endocrinology · 2025Article
- Phylogenetic and transcriptomic characterization of insulin and growth factor receptor tyrosine kinases in crustaceans.Frontiers in endocrinology · 2024Article
- Monosex Populations of the Giant Freshwater PrawnInternational journal of molecular sciences · 2023Review
- Analysis of mRNA and MicroRNA Expression Profiles of Nervous Tissues and Reproductive Tissues in Male Procambarus clarkii After Silencing IAG.Marine biotechnology (New York, N.Y.) · 2023Article
- Ferroptosis precedes apoptosis to facilitate specific death signalling by fatty acids.Proceedings. Biological sciences · 2023Article
- Review
- Identification of Crustacean Female Sex Hormone Receptor Involved in Sexual Differentiation of a Hermaphroditic Shrimp.Biomolecules · 2023Article
- Isolation of an Insulin-Like Receptor Involved in the Testicular Development of the Mud CrabInternational journal of molecular sciences · 2023Article
- Identification of a Putative CFSH Receptor Inhibiting IAG Expression in Crabs.International journal of molecular sciences · 2023Article
- Eyestalk transcriptome and methyl farnesoate titers provide insight into the physiological changes in the male snow crab, Chionoecetes opilio, after its terminal molt.Scientific reports · 2023Article
- Article
- Putative Role of CFSH in the Eyestalk-AG-Testicular Endocrine Axis of the Swimming CrabAnimals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The androgenic gland (AG)-a unique crustacean endocrine organ that secretes factors such as the insulin-like androgenic gland (IAG) hormone-is a key player in crustacean sex differentiation processes. IAG expression induces masculinization, while the absence of the AG or a deficiency in IAG expression results in feminization. Therefore, by virtue of its universal role as a master regulator of crustacean sexual development, the IAG hormone may be regarded as the sexual "IAG-switch." The switch functions within an endocrine axis governed by neuropeptides secreted from the eyestalks, and interacts downstream with specific insulin receptors at its target organs. In recent years, IAG hormones have been found-and sequenced-in dozens of decapod crustacean species, including crabs, prawns, crayfish and shrimps, bearing different types of reproductive strategies-from gonochorism, through hermaphroditism and intersexuality, to parthenogenesis. The IAG-switch has thus been the focus of efforts to manipulate sex developmental processes in crustaceans. Most sex manipulations were performed using AG ablation or knock-down of the
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