ArticleFrontiers in neurology2020
Simulation of the Strain Amplification in Sulci Due to Blunt Impact to the Head.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion.Neurobiology of disease · 2026Review
- Effect of modeling subject-specific cortical folds on brain injury risk prediction under blunt impact loading.Biomechanics and modeling in mechanobiology · 2026Article
- Soccer Heading Exposure-Dependent Microstructural Injury at Depths of Sulci in Adult Amateur Players.Neurology · 2025Article
- Orbitofrontal Gray-White Interface Injury and the Association of Soccer Heading With Verbal Learning.JAMA network open · 2025Article
- Does white matter and vascular injury from repetitive head impacts lead to a novel pattern on T2 FLAIR MRI? A hypothesis proposal and call for research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue.PloS one · 2025Article
- Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function.Brain : a journal of neurology · 2024Article
- Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players.JAMA network open · 2024Article
- Sulcal Cavitation in Linear Head Acceleration: Possible Correlation With Chronic Traumatic Encephalopathy.Frontiers in neurology · 2022Article
- Approaches for Monitoring Warfighter Blast-related Exposures in Training to Develop Effective Safety Standards.Military medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) has become a concern in sports, automobile accidents and combat operations. A better understanding of the mechanics leading to a TBI is required to cope with both the short-term life-threatening effects and long-term effects of TBIs, such as the development chronic traumatic encephalopathy (CTE). Kornguth et al. (1) proposed that an inflammatory and autoimmune process initiated by a water hammer effect at the bases of the sulci of the brain is a mechanism of TBI leading to CTE. A major objective of this study is to investigate whether the water hammer effect is present due to blunt impacts through the use of computational models. Frontal blunt impacts were simulated with 2D finite element models developed to capture the biofidelic geometry of a human head. The models utilized the Arbitrary Lagrangian Eulerian (ALE) method to model a layer of cerebrospinal fluid (CSF) as a deforming fluid allowing for CSF to move in and out of sulci. During the simulated impacts, CSF was not observed to be driven into the sulci during the transient response. However, elevated shear strain levels near the base of the sulci were exhibited. Further, increased shear strain was present when differentiation between white and gray matter was taken into account. Both of the results support clinical observations of (1).
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