Evidence map›Paper›PMID 33013637›Full record

ArticleFrontiers in neurology2020

COVID-19-Related Anosmia: The Olfactory Pathway Hypothesis and Early Intervention.

Alessandra Gori, Fabrizio Leone, Lorenzo Loffredo, Bianca Laura Cinicola, Giulia Brindisi, Giovanna De Castro, Alberto Spalice, Marzia Duse, Anna Maria Zicari

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In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandra GoriDepartment of Pediatrics, Sapienza University, Rome, Italy.
Fabrizio LeoneDepartment of Pediatrics, Sapienza University, Rome, Italy.
Lorenzo LoffredoDepartment of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
Bianca Laura CinicolaDepartment of Pediatrics, Sapienza University, Rome, Italy.
Giulia BrindisiDepartment of Pediatrics, Sapienza University, Rome, Italy.
Giovanna De CastroDepartment of Pediatrics, Sapienza University, Rome, Italy.
Alberto SpaliceChild Neurology Division, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.
Marzia DuseDepartment of Pediatrics, Sapienza University, Rome, Italy.
Anna Maria ZicariDepartment of Pediatrics, Sapienza University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anosmia is a well-described symptom of Corona Virus Disease 2019 (COVID-19). Several respiratory viruses are able to cause post-viral olfactory dysfunction, suggesting a sensorineural damage. Since the olfactory bulb is considered an immunological organ contributing to prevent the invasion of viruses, it could have a role in host defense. The inflammatory products locally released in COVID-19, leading to a local damage and causing olfactory loss, simultaneously may interfere with the viral spread into the central nervous system. In this context, olfactory receptors could play a role as an alternative way of SARS-CoV-2 entry into cells locally, in the central nervous system, and systemically. Differences in olfactory bulb due to sex and age may contribute to clarify the different susceptibility to infection and understand the role of age in transmission and disease severity. Finally, evaluation of the degree of functional impairment (grading), central/peripheral anosmia (localization), and the temporal course (evolution) may be useful tools to counteract COVID-19.

Indexed as

anosmiaCOVID-19olfactory bulbolfactory receptorsSARS-CoV-2

Identifiers

PMID33013637
PMCPMC7511833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.