Evidence map›Paper›PMID 33013490›Full record

ArticleFrontiers in physiology2020

The Probable, Possible, and Novel Functions of ERp29.

Margaret Brecker, Svetlana Khakhina, Tyler J Schubert, Zachary Thompson, Ronald C Rubenstein

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  5. Endoplasmic Reticulum Proteins Impact Penetrance in aInternational journal of molecular sciences · 2025
    Article
  6. Decoding PDI diversity: Insights into structure, domains, and functionality in sorghum.Computational and structural biotechnology journal · 2025
    Article
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  15. The Journey of Cancer Cells to the Brain: Challenges and Opportunities.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Margaret BreckerCystic Fibrosis Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Svetlana KhakhinaCystic Fibrosis Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Tyler J SchubertCystic Fibrosis Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Zachary ThompsonCystic Fibrosis Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Ronald C RubensteinCystic Fibrosis Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Children's Hospital of Philadelphia · USWashington University in St. Louis · US

Funding

ERP29: PROMOTING ION CHANNEL BIOGENESIS FROM THE ER LUMENR01HL135670 · NHLBI · WASHINGTON UNIVERSITY · PI RUBENSTEIN, RONALD C · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL135670
6 · The paper itself

Abstract

The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial sodium channel (ENaC), thyroglobulin, connexin 43 hemichannels, and proinsulin. ERp29 is hypothesized to promote ER to

Indexed as

chaperoneCOP IIendoplasmic reticulumERp29escortGolgisecretory pathwaytrafficking

Identifiers

PMID33013490
PMCPMC7506106
OpenAlexW3084194954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.