Evidence map›Paper›PMID 33013487›Full record

ArticleFrontiers in physiology2020

Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells.

Luigia Rossi, Francesca Pierigè, Marco Agostini, Noemi Bigini, Veronica Termopoli, Yingting Cai, Fang Zheng, Chang-Guo Zhan, Donald W Landry, Mauro Magnani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. A Microbial Cocaine Bioreporter.Sensors (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Luigia RossiDepartment of Biomolecular Sciences, University of Urbino, Urbino, Italy.
Francesca PierigèDepartment of Biomolecular Sciences, University of Urbino, Urbino, Italy.
Marco AgostiniLaboratory of Toxicology, ASUR AV1, Pesaro, Italy.
Noemi BiginiDepartment of Biomolecular Sciences, University of Urbino, Urbino, Italy.
Veronica TermopoliDepartment of Pure and Applied Sciences, University of Urbino, Urbino, Italy.
Yingting CaiMolecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, Lexington, KY, United States.
Fang ZhengMolecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, Lexington, KY, United States.
Chang-Guo ZhanMolecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, Lexington, KY, United States.
Donald W LandryDepartment of Medicine, Columbia University, New York, NY, United States.
Mauro MagnaniDepartment of Biomolecular Sciences, University of Urbino, Urbino, Italy.
University of Kentucky · USUniversity of Urbino · ITErydel (Italy) · ITColumbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301, although improving

Indexed as

cocaine degradationcocaine esterasecocaine use disorderE196-301 stabilityRBP 8000 stabilityred blood cells as drug delivery system

Identifiers

PMID33013487
PMCPMC7511699
OpenAlexW3084337575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.