Evidence map›Paper›PMID 33013454›Full record

ReviewFrontiers in physiology2020

Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na

Olga Dmitrievna Lopina, Artem Mikhaylovich Tverskoi, Elizaveta Andreevna Klimanova, Svetlana Vadimovna Sidorenko, Sergei Nikolaevich Orlov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Digoxin and its NaBioorganic & medicinal chemistry · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Olga Dmitrievna LopinaDepartment of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Artem Mikhaylovich TverskoiEngelhardt Institute of Molecular Biology, Russian Academy of Sciences (RAS), Moscow, Russia.
Elizaveta Andreevna KlimanovaDepartment of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Svetlana Vadimovna SidorenkoDepartment of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Sergei Nikolaevich OrlovLaboratory of Biological Membranes, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Lomonosov Moscow State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na

Indexed as

cardiotonic steroidscell deathgene expressionintracellular Na+ and K+intracellular signalingNa,K-ATPaseouabain

Identifiers

PMID33013454
PMCPMC7498651
OpenAlexW3083696578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.