Evidence map›Paper›PMID 33013418›Full record

ArticleFrontiers in pharmacology2020

The Effectiveness of Clinical Pharmacist-Led Consultation in the Treatment of Infectious Diseases: A Prospective, Multicenter, Cohort Study.

Jiaxing Zhang, Xiaosi Li, Rui He, Wenyi Zheng, Joey Sum-Wing Kwong, Ling Lu, Tianyi Lv, Rong Huang, Mei He, Xiaoyan Li and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  9. The role of the clinical pharmacist in antimicrobial stewardship in Asia: A review.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022
    Review
  10. Review
  11. Hypoalbuminemia as Surrogate and Culprit of Infections.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

Jiaxing ZhangDepartment of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, China.
Xiaosi LiDepartment of Pharmacy, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China.
Rui HeExperimental Cancer Medicine, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Wenyi ZhengExperimental Cancer Medicine, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Joey Sum-Wing KwongGlobal Health Nursing, Graduate School of Nursing Science, St. Luke's International University, Tokyo, Japan.
Ling LuDepartment of Pharmacy, The Second People's Hospital of Guiyang, Guiyang, China.
Tianyi LvDepartment of Pharmacy, Xingyi People's Hospital, Xingyi, China.
Rong HuangDepartment of Pharmacy, Qian Xi Nan People's Hospital, Xingyi, China.
Mei HeDepartment of Pharmacy, The First People's Hospital of Bijie City, Bijie, China.
Xiaoyan LiDepartment of Pharmacy, Tongren Municipal People's Hospital, Tongren, China.
Xue WangDepartment of Pharmacy, The People's Hospital of Qiannan, Duyun, China.
Qin FangDepartment of Pharmacy, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Lingyu WeiDepartment of Pharmacy, Guizhou Cancer Hospital, Guiyang, China.
Yang LiuDepartment of Pharmacy, The Second Affiliated Hospital of GuiZhou Medical University, Kaili, China.
Shuya ChenDepartment of Pharmacy, The First People's Hospital of Guiyang, Guiyang, China.
Xiaogai QinDepartment of Pharmacy, Affiliated Wudang Hospital of Guizhou Medical University, Guiyang, China.
Juan XieDepartment of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, China.
Affiliated Hospital of Guizhou Medical University · CNGuizhou Provincial People's Hospital · CNThe First People's Hospital of Guiyang · CNGuizhou Cancer Hospital · CNKarolinska Institutet · SEKarolinska University Hospital · SEQiannan Normal College For Nationalities · CNSt. Luke's International University · JPTibet Autonomous Region People's Hospital · CNTongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) is a serious global health threat and leads to a huge challenge to infectious diseases (ID) treatment. To tackle AMR, regional 'Antimicrobial Stewardship Programs' (ASP) have been implemented in many countries. Due to insufficient clinical pharmacy resources, a major intervention mode of ASP in China is through clinical pharmacist-led consultation (CPC). The current study aims to prospectively evaluate this intervention and compare the effectiveness of CPC served by ID and non-ID clinical pharmacists.

methodsWe conducted a prospective and multicenter cohort study based on a regional registry database in 17 hospitals in Western China, including consecutive patients with ID between April 2017 and December 2019. Baseline characteristics including sex, age, liver and kidney function, comorbidity, infection severity were prospectively collected and recorded. The main exposure of interest was whether the attending physician adopted recommendations of the clinical pharmacist in the therapeutic scheme. The outcome was the infection effective response, assessed during day 3-7 after completing CPC. Multivariate analyses were performed by generalized linear mixed models.

resultsA total of 2,663 ID patients were included in the final analysis according to the predesigned inclusion and exclusion criteria. The number of patients whose treatment followed and did not follow the pharmacists' suggestion was 2,529 and 134, respectively. CPC intervention could improve the ID patient prognosis in the context of other confounders controlled (

conclusionThis study suggests that CPC is a promising pharmacist-led intervention to improve ID treatment, and it can achieve standardization among clinical pharmacists with different backgrounds by some measures. Policy/decision-makers should promote this intervention mode in developing countries or regions where there is an insufficient number of clinical pharmacists.

Indexed as

Antimicrobial Stewardship Programclinical pharmacist-led consultationcohort studyinfectious diseasespharmaceutical service

Identifiers

PMID33013418
PMCPMC7506045
OpenAlexW3084158078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.