Evidence map›Paper›PMID 33013352›Full record

ArticleFrontiers in aging neuroscience2020

Huntingtin Aggregates in the Olfactory Bulb in Huntington's Disease.

Blake Highet, Birger Victor Dieriks, Helen C Murray, Richard L M Faull, Maurice A Curtis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  13. Olfactory Dysfunction in Huntington's Disease.Journal of Huntington's disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Blake HighetDepartment of Anatomy and Medical Imaging, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
Birger Victor DieriksDepartment of Anatomy and Medical Imaging, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
Helen C MurrayDepartment of Anatomy and Medical Imaging, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
Richard L M FaullDepartment of Anatomy and Medical Imaging, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
Maurice A CurtisDepartment of Anatomy and Medical Imaging, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
University of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfactory deficits are an early and prevalent non-motor symptom of Huntington's disease (HD). In other neurodegenerative diseases where olfactory deficits occur, such as Alzheimer's disease and Parkinson's disease, pathological protein aggregates (tau, β-amyloid, α-synuclein) accumulate in the anterior olfactory nucleus (AON) of the olfactory bulb (OFB). Therefore, in this study we determined whether aggregates are also present in HD OFBs; 13 HD and five normal human OFBs were stained for mutant huntingtin (mHtt), tau, β-amyloid, TDP-43, and α-synuclein. Our results show that mHtt aggregates detected with 1F8 antibody are present within all HD OFBs, and mHtt aggregate load in the OFB does not correlate with Vonsattel grading scores. The majority of the aggregates were located in the AON and in similar abundance in each anatomical segment of the AON. No mHtt aggregates were found in controls; 31% of HD cases also contained tau neurofibrillary tangles within the AON. This work demonstrates HD pathology in the OFB and indicates that disease-specific protein aggregation in the AON is a common feature of neurodegenerative diseases that show olfactory deficits.

Indexed as

anterior olfactory nucleushuntingtin aggregatesHuntington’s diseaseolfactory bulbtau

Identifiers

PMID33013352
PMCPMC7461834
OpenAlexW3070810602

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.