Evidence map›Paper›PMID 33013333›Full record

ArticleFrontiers in systems neuroscience2020

The Estradiol Synthesis Inhibitor Formestane Diminishes the Ability of Sevoflurane to Induce Neurodevelopmental Abnormalities in Male Rats.

Jie Wang, Baofeng Yang, Lingsha Ju, Jiaojiao Yang, Andrea Allen, Jiaqiang Zhang, Anatoly E Martynyuk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jie WangDepartment of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Baofeng YangDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.
Lingsha JuDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.
Jiaojiao YangDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.
Andrea AllenDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.
Jiaqiang ZhangDepartment of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Anatoly E MartynyukDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.
Florida College · USUniversity of Florida · USHenan Provincial People's Hospital · CNZhengzhou University · CN

Funding

Role of the limbic-hypothalamic-pituitary-adrenal axis and gamma-aminobutyric acid type A receptor-mediated excitation in the developmental central and systemic effects of neonatal anesthesiaR01NS091542 · NINDS · UNIVERSITY OF FLORIDA · PI MARTYNYUK, ANATOLY E · 2015 to 2018
$1.4M
NINDS NIH HHS R01 NS091542
6 · The paper itself

Abstract

backgroundIn rodents, the period of increased vulnerability to the developmental effects of general anesthetics coincides with the period of age-specific organizing (masculinizing) effects of the major female sex hormone 17β-estradiol (E2) in the male brain and excitatory GABA type A receptor (GABA

methodsMale Sprague-Dawley rats were pretreated with the inhibitors of E2 synthesis, formestane, or the Na

resultsThe rats neonatally exposed to sevoflurane responded to repeated exposure to sevoflurane with increased EEG-detectable seizures (

conclusionThese results, along with previously published data, suggest that sevoflurane-enhanced E2 synthesis and excitatory GABA

Indexed as

behavioral abnormalitiescorticosteroneEEG seizuresestradiolexcitatory GABAA receptor signalingsevoflurane

Identifiers

PMID33013333
PMCPMC7498728
OpenAlexW3083106208

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.