ReviewFrontiers in neuroanatomy2020
The Dual Nature of Onuf's Nucleus: Neuroanatomical Features and Peculiarities, in Health and Disease.
Review in Frontiers in neuroanatomy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Targeting the neuro-immune axis: immunological mechanisms and therapeutic strategies in male sexual dysfunction.Journal of neuroinflammation · 2026Review
- The cerebro-pelvic axis: a unified framework linking higher brain function, pelvic floor control, and lower urinary tract dysfunction.Frontiers in neuroscience · 2026Article
- Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus.Physiological reports · 2025Article
- The Neuroanatomical Correlates of Bladder Filling: An Activation Likelihood Estimation Meta-Analysis of Functional Neuroimaging Studies.Neurology international · 2025Review
- A galanin-positive population of lumbar spinal cord neurons modulates sexual arousal and copulatory behavior in male mice.Nature communications · 2025Article
- Maturation of Micturition-Related Neural Circuits That Control Pelvic Visceromotor Functions in Postnatal Rats.The European journal of neuroscience · 2025Article
- Conus medullaris and cauda equina syndrome as complications of non-imaging guided epidural steroid injection: two case reports with comprehensive interdisciplinary work-up.BMC neurology · 2025Article
- Article
- Sexual Dimorphism of Spinal Neural Circuits Controlling the Mouse External Urethral Sphincter With and Without Spinal Cord Injury.The Journal of comparative neurology · 2024Article
- Complex Dysautonomia in a Patient With Cerebral Cavernous Malformations Due to a KRIT1 Pleiotropic Gene Mutation.Cureus · 2024Article
- The differences in the anatomy of the thoracolumbar and sacral autonomic outflow are quantitative.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Noradrenergic Pathways Involved in Micturition in an Animal Model of Hydrocephalus-Implications for Urinary Dysfunction.Biomedicines · 2024Article
- Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and functional correlates.Brain structure & function · 2024Review
- Urethral pharmacological mechanisms incontinence and bladder emptying: An updated review.Bladder (San Francisco, Calif.) · 2024Review
- Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.Nature communications · 2023Article
- Anatomical Aspects of Neurogenic Bladder and the Approach in Its Management: A Narrative Review.Cureus · 2022Review
- Autonomic dysfunction as the initial presentation in spinocerebellar ataxia type 3: A case report and review of the literature.Frontiers in neurology · 2022Article
- Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1Frontiers in endocrinology · 2022Article
- Female sexual dysfunction in multiple system atrophy: does it matter?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Onuf's nucleus is a small group of neurons located in the ventral horns of the sacral spinal cord. The motor neurons (MNs) of Onuf's nucleus innervate striated voluntary muscles of the pelvic floor and are histologically and biochemically comparable to the other somatic spinal MNs. However, curiously, these neurons also show some autonomic-like features as, for instance, they receive a strong peptidergic innervation. The review provides an overview of the histological, biochemical, metabolic, and gene expression peculiarities of Onuf's nucleus. Moreover, it describes the aging-related pathologies as well as several traumatic and neurodegenerative disorders in which its neurons are involved: indeed, Onuf's nucleus is affected in Parkinson's disease (PD) and Shy-Drager Syndrome (SDS), whereas it is spared in Amyotrophic Lateral Sclerosis (ALS), Spinal Muscular Atrophy (SMA), Duchenne Muscular Dystrophy (DMD). We summarize here the milestone studies that have contributed to clarifying the nature of Onuf's neurons and in understanding what makes them either vulnerable or resistant to damage. Altogether, these works can offer the possibility to develop new therapeutic strategies for counteracting neurodegeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.