Evidence map›Paper›PMID 33013329›Full record

ArticleFrontiers in neuroanatomy2020

Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons.

Cindy F Yang, Euiseok J Kim, Edward M Callaway, Jack L Feldman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroanatomy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Dynamic Respiration-Neural Coupling in Substantia Nigra across Sleep and Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  15. Article
  16. Article
  17. Cyanotic apnea in stiff person syndrome.Acta neurologica Belgica · 2025
    Article
  18. Article
  19. Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cindy F YangDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Euiseok J KimSystems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States.
Edward M CallawaySystems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States.
Jack L FeldmanDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Salk Institute for Biological Studies · USUniversity of California, Los Angeles · US

Funding

Local Connections of Inhibitory Cortical NeuronsR01MH063912 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CALLAWAY, EDWARD M · 2001 to 2020
$8.4M
Organization and Function of Visual Cortical Feedback SystemsR01EY022577 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EDWARD M CALLAWAY · 2012 to 2026
$8.0M
Neural control of breathingR35HL135779 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2017 to 2023
$5.6M
Functional Dissection of Medullary Respiratory MicrocircuitsR01NS072211 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2010 to 2020
$3.8M
Genetic mapping of neural circuits that control breathingF32HL126522 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, CINDY · 2015 to 2016
$112k
NEI NIH HHS R01 EY022577NHLBI NIH HHS F32 HL126522NHLBI NIH HHS R35 HL135779NIMH NIH HHS R01 MH063912NINDS NIH HHS R01 NS072211
6 · The paper itself

Abstract

The key driver of breathing rhythm is the preBötzinger Complex (preBötC) whose activity is modulated by various functional inputs, e.g., volitional, physiological, and emotional. While the preBötC is highly interconnected with other regions of the breathing central pattern generator (bCPG) in the brainstem, there is no data about the direct projections to either excitatory and inhibitory preBötC subpopulations from other elements of the bCPG or from suprapontine regions. Using modified rabies tracing, we identified neurons throughout the brain that send monosynaptic projections to identified excitatory and inhibitory preBötC neurons in mice. Within the brainstem, neurons from sites in the bCPG, including the contralateral preBötC, Bötzinger Complex, the nucleus of the solitary tract (NTS), parafacial region (pF

Indexed as

afferent tracingbreathingmodified rabiesneural circuitpreBötzinger Complexrespirationretrograde tracing

Identifiers

PMID33013329
PMCPMC7507425
OpenAlexW3083563689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.