Evidence map›Paper›PMID 33013297›Full record

ArticleFrontiers in neuroscience2020

Telmisartan, an Antagonist of Angiotensin II Receptors, Accentuates Voltage-Gated Na

Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Inhibition of Voltage-Gated NaInternational journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Activation of Voltage-Gated NaBiomedicines · 2022
    Article
  9. Zingerone Modulates Neuronal Voltage-Gated NaInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ming-Chi LaiDepartment of Pediatrics, Chi-Mei Medical Center, Tainan, Taiwan.
Sheng-Nan WuDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chin-Wei HuangDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chi Mei Medical Center · TWNational Cheng Kung University · TWNational Cheng Kung University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telmisartan (TEL), a non-peptide blocker of the angiotensin II type 1 receptor, is a widely used antihypertensive agent. Nevertheless, its neuronal ionic effects and how they potentially affect neuronal network excitability remain largely unclear. With the aid of patch-clamp technology, the effects of TEL on membrane ion currents present in hippocampal neurons (mHippoE-14 cells) were investigated. For additional characterization of the effects of TEL on hippocampal neuronal excitability, we undertook

Indexed as

hippocampuspilocarpineseizuretelmisartanvoltage-gated Na+ current

Identifiers

PMID33013297
PMCPMC7499822
OpenAlexW3083216898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.