Evidence map›Paper›PMID 33013180›Full record

ReviewProcess biochemistry (Barking, London, England)2021

Topical review on nano-vaccinology: Biochemical promises and key challenges.

Tean Zaheer, Kaushik Pal, Iqra Zaheer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Process biochemistry (Barking, London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tean ZaheerDepartment of Parasitology, University of Agriculture, Faisalabad, Faisalabad 38040, Pakistan.
Kaushik PalFederal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro RJ, 21941-901, Brazil.
Iqra ZaheerDepartment of Pathology, University of Agriculture, Faisalabad, Faisalabad 38040, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomaterials have wide-ranging biomedical applications in prevention, treatment and control of diseases. Nanoparticle based vaccines have proven prodigious prophylaxis of various infectious and non-infectious diseases of human and animal concern. Nano-vaccines outnumber the conventional vaccines by virtue of plasticity in physio-chemical properties and ease of administration. The efficacy of nano-based vaccines may be attributed to the improved antigen stability, minimum immuno-toxicity, sustained release, enhanced immunogenicity and the flexibility of physical features of nanoparticles. Based on these, the nano-based vaccines have potential to evoke both cellular and humoral immune responses. Targeted and highly specific immunological pathways required for solid and long lasting immunity may be achieved with specially engineered nano-vaccines. This review presents an insight into the prevention of infectious diseases (of bacterial, viral and parasitic origin) and non-infectious diseases (cancer, auto-immune diseases) using nano-vaccinology. Additionally, key challenges to the effective utilization of nano-vaccines from bench to clinical settings have been highlighted as research domains for future.

Indexed as

CAPN, calcium-phosphate nanoparticlesChi-Alg, chitosan alginateCNT, carbon nanotubeCOVID-19, Corona virus disease-2019HIV, human immune deficiency virusHPV, human papilloma virusIgA, immunoglobulin AImmunityISCOMS, immune stimulating complexesMERS, Middle-East respiratory syndromeMRSA, methcillin resistant Staphylococcus aureusNanoparticlesNMVs, nano multilamellar lipid vesiclesPathogensPLGA, poly(lactic-co-glycolic acid)PreventionPSNP, polystyrene nanoparticlesSAPN, Self-Assembling Protein NanoparticleSARS-CoV-1, severe acute respiratory syndrome Coronavirus-1VaccineVLP, virus like particles

Identifiers

PMID33013180
PMCPMC7521878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.