Evidence map›Paper›PMID 33013097›Full record

ArticleJournal of emergencies, trauma, and shock

Role of Inhaled Corticosteroids for Asthma Exacerbation in Children: An Updated Meta-Analysis.

Kanlayanee Sawanyawisuth, Paiboon Chattakul, Sittichai Khamsai, Watchara Boonsawat, Arinrada Ladla, Verajit Chotmongkol, Panita Limpawattana, Jarin Chindaprasirt, Vichai Senthong, Chalongchai Phitsanuwong and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of emergencies, trauma, and shock. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Kanlayanee SawanyawisuthDepartment of Biochemistry, Faculty of Medicine, Khon Kaen, Thailand.
Paiboon ChattakulSleep Apnea Research Group, Research Center in Back, Neck and Other Joint Pain and Human Performance, Khon Kaen University, Khon Kaen, Thailand.
Sittichai KhamsaiSleep Apnea Research Group, Research Center in Back, Neck and Other Joint Pain and Human Performance, Khon Kaen University, Khon Kaen, Thailand.
Watchara BoonsawatDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Arinrada LadlaDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Verajit ChotmongkolDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Panita LimpawattanaDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Jarin ChindaprasirtDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Vichai SenthongDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Chalongchai PhitsanuwongDepartment of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
Kittisak SawanyawisuthSleep Apnea Research Group, Research Center in Back, Neck and Other Joint Pain and Human Performance, Khon Kaen University, Khon Kaen, Thailand.
Khon Kaen University · THUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies showed that inhaled corticosteroids (ICS) may be a potential treatment in acute asthma exacerbation in children. This study was an update meta-analysis on the roles of ICS in the management of acute asthma exacerbation in children presenting to the hospital. MATERIALS AND

methodsPublished articles with key words of ICS for asthma exacerbation, asthma attacks, and acute asthma in children aged under 18 years in the hospital setting with outcome of hospital admission between 2009 and 2018 were enrolled. The databases used in this study were Medline, Scopus, and Web of Science. Odds ratio of comparison between ICS and other treatments on hospital admissions was calculated.

resultsThere were 311 eligible studies met the searching criteria; seven eligible studies for the analysis; comprised of three meta-analysis and four added studies. The ICS had a significant reduction in hospital admission compared with placebo in overall with odds ratio of 0.63 (95% confidence interval [CI]: 0.41-0.96) and in moderate-to-severe group with odds ratio of 0.17 (95% CI: 0.05-0.51). Comparing with systemic corticosteroid (SC), ICS had significantly lower hospital admissions overall and in mild-to-moderate group with odds ratios of 0.63 and 0.26, respectively. The combination of ICS and SC had odds ratio of 0.75 (95% CI: 0.57-0.99) over SC in moderate-to-severe asthma exacerbation.

conclusionsICS significantly reduced hospital admission in asthma exacerbation in children. It may be used alone for mild-to-moderate asthma exacerbation and combination with SC for moderate-to-severe asthma exacerbation.

Indexed as

Admissionhospitalizationsystemic corticosteroids

Identifiers

PMID33013097
PMCPMC7472813
OpenAlexW3034750664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.