ArticleJournal of perinatology : official journal of the California Perinatal Association2021
Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Assessment of iron sufficiency in premature infants treated with darbepoetin using conventional and novel erythrocyte metrics.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Hyperferritinemia among very-low-birthweight infants in Thailand: a prospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency.Nutrients · 2024Review
- Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Impact and interactions between risk factors on the iron status of at-risk neonates.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Maternal diabetes and the role of neonatal reticulocyte hemoglobin content as a biomarker of iron status in the perinatal period.Frontiers in endocrinology · 2022Article
- Neonatal Reference Intervals for the Complete Blood Count Parameters MicroR and HYPO-He: Sensitivity Beyond the Red Cell Indices for Identifying Microcytic and Hypochromic Disorders.The Journal of pediatrics · 2021Article
- Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.Blood cells, molecules & diseases · 2021Article
- Is the erythropoietin-erythroferrone-hepcidin axis intact in human neonates?Blood cells, molecules & diseases · 2021Article
- Iron deficiency in newborn infants: global rewards for recognizing and treating this silent malady.Newborn (Clarksville, Md.)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine why serum ferritin and reticulocyte hemoglobin (RET-He), drawn to assess neonatal iron sufficiency, sometimes have markedly discordant results. STUDY
designRetrospective records review of five NICUs over 28 months, identifying all patients with a ferritin and RET-He within 48 h. We examined records of all who had marked discordance (one value >95th % reference interval, the other <5th %).
resultsOf 190 paired ferritin and RET-He measurements, 16 (8%) were markedly discordant. Fifteen of the 16 discordant samples involved a high ferritin and a low RET-He. In these, low MCV and high %Micro-R, and low MCH and high %HYPO-He were present. In total, 8 of the 15 had laboratory or clinical evidence of an inflammatory process and five had suspicion of infection documented.
conclusionsWhen ferritin and RET-He were discordant, erythrocyte microcytosis and hypochromasia suggested that the RET-He gave the more accurate interpretation; that iron deficiency was likely present.
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