ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Acute Posttraumatic Symptoms Are Associated With Multimodal Neuroimaging Structural Covariance Patterns: A Possible Role for the Neural Substrates of Visual Processing in Posttraumatic Stress Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study.Brain connectivity · 2023Pooled it
- A visual cortex origin of trauma memory intrusions: integrated evidence from TMS and fMRI.Psychological medicine · 2026Article
- Impacts of early life adversity on the neurocircuitry of emotional memory in children.Development and psychopathology · 2025Article
- Association Between Acute Plasma Glial Fibrillary Acidic Protein Levels and White Matter Integrity in Recent Trauma Survivors.Journal of neurotrauma · 2025Article
- Posttraumatic Stress Disorder-Related Differences in Neural Connectivity Among Female Trauma Survivors.Biological psychiatry global open science · 2025Article
- The value of multimodal neuroimaging in the diagnosis and treatment of post-traumatic stress disorder: a narrative review.Translational psychiatry · 2025Review
- Early processing of traumatic material and contextual information in posttraumatic stress disorder and its relation to memory impairments.Scientific reports · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder.BMC psychiatry · 2025Article
- Traumatic stress alters neural reactivity to visual stimulation.NPP - digital psychiatry and neuroscience · 2025Article
- PTSD-related differences in resting-state functional connectivity and associations with sex hormones.medRxiv : the preprint server for health sciences · 2024Article
- Population-level normative models reveal race- and socioeconomic-related variability in cortical thickness of threat neurocircuitry.Communications biology · 2024Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- White matter predictors of PTSD: Testing different machine learning models in a sample of Black American women.Journal of psychiatric research · 2023Article
- Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.Molecular psychiatry · 2023Article
- Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.Biological psychiatry global open science · 2023Article
- Study on the changes of Structural Covariance Network in post-traumatic stress disorder.Brain imaging and behavior · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough aspects of brain morphology have been associated with chronic posttraumatic stress disorder (PTSD), limited work has investigated multimodal patterns in brain morphology that are linked to acute posttraumatic stress severity. In the present study, we utilized multimodal magnetic resonance imaging to investigate if structural covariance networks (SCNs) assessed acutely following trauma were linked to acute posttraumatic stress severity.
methodsStructural magnetic resonance imaging data were collected around 1 month after civilian trauma exposure in 78 participants. Multimodal magnetic resonance imaging data fusion was completed to identify combinations of SCNs, termed structural covariance profiles (SCPs), related to acute posttraumatic stress severity collected at 1 month. Analyses assessed the relationship between participant SCP loadings, acute posttraumatic stress severity, the change in posttraumatic stress severity from 1 to 12 months, and depressive symptoms.
resultsWe identified an SCP that reflected greater gray matter properties of the anterior temporal lobe, fusiform face area, and visual cortex (i.e., the ventral visual stream) that varied curvilinearly with acute posttraumatic stress severity and the change in PTSD symptom severity from 1 to 12 months. The SCP was not associated with depressive symptoms.
conclusionsWe identified combinations of multimodal SCNs that are related to variability in PTSD symptoms in the early aftermath of trauma. The identified SCNs may reflect patterns of neuroanatomical organization that provide unique insight into acute posttraumatic stress. Furthermore, these multimodal SCNs may be potential candidates for neural markers of susceptibility to both acute posttraumatic stress and the future development of PTSD.
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