ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Investigating the demographic history of Japan using ancient oral microbiota.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 34 citations in OpenAlex.
- Lifestyle Impacts the Oral Microbiome of Classical and Post-Classical Societies in Italy.American journal of biological anthropology · 2026Article
- The Oral Microbiome of King Richard III of England.American journal of biological anthropology · 2026Article
- Insights into demographic and cultural influences on the oral microbiome from historical Japanese dental calculus.Scientific reports · 2026Article
- Wet Lab Protocols Matter: Choice of DNA Extraction and Library Preparation Protocols Bias Ancient Oral Microbiome Recovery.Molecular ecology resources · 2025Article
- Ancient DNA and biomarkers from artefacts: insights into technology and cultural practices in Neolithic Europe.Proceedings. Biological sciences · 2025Article
- Streptococcus abundance and oral site tropism in humans and non-human primates reflects host and lifestyle differences.NPJ biofilms and microbiomes · 2025Article
- Exploring the potential of dental calculus to shed light on past human migrations in Oceania.Nature communications · 2024Article
- Oral microbial diversity in 18th century African individuals from South Carolina.Communications biology · 2024Article
- Paleomicrobiology: Tracking the past microbial life from single species to entire microbial communities.Microbial biotechnology · 2024Review
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- A relational framework for microbiome research with Indigenous communities.Nature microbiology · 2023Review
- Dental calculus as a proxy for animal microbiomes.Quaternary international : the journal of the International Union for Quaternary Research · 2023Article
- Ancient oral microbiomes support gradual Neolithic dietary shifts towards agriculture.Nature communications · 2022Article
- Metagenomic analysis of ancient dental calculus reveals unexplored diversity of oral archaeal Methanobrevibacter.Microbiome · 2021Article
- Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Review
- Comparison of Periodontal Bacteria of Edo and Modern Periods Using Novel Diagnostic Approach for Periodontitis With Micro-CT.Frontiers in cellular and infection microbiology · 2021Article
- Insights into health and disease from ancient biomolecules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While microbial communities in the human body (microbiota) are now commonly associated with health and disease in industrialised populations, we know very little about how these communities co-evolved and changed with humans throughout history and deep prehistory. We can now examine these communities by sequencing ancient DNA preserved within calcified dental plaque (calculus), providing insights into the origins of disease and their links to human history. Here, we examine ancient DNA preserved within dental calculus samples and their associations with two major cultural periods in Japan: the Jomon period hunter-gatherers approximately 3000 years before present (BP) and the Edo period agriculturalists 400-150 BP. We investigate how human oral microbiomes have changed in Japan through time and explore the presence of microorganisms associated with oral diseases (e.g. periodontal disease, dental caries) in ancient Japanese populations. Finally, we explore oral microbial strain diversity and its potential links to ancient demography in ancient Japan by performing phylogenomic analysis of a widely conserved oral species-
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