ArticleInternal and emergency medicine2021
Lung ultrasound as diagnostic tool for SARS-CoV-2 infection.
Article in Internal and emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178160 (Lung Ultrasound-Guided PEEP Titration Versus Standard Protocol in Patients With COVID-19 ARDS Treated With CPAP), which is not on this map. Cited by 30 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Ultrasound-Guided PEEP Titration Versus Standard Protocol in Patients With COVID-19 ARDS Treated With CPAP: a Single Center Prospective Trial
Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Lung Ultrasound Score in COVID-19 Patients Correlates with POThe western journal of emergency medicine · 2024Pooled it
- Lung ultrasound score severity cut-off points in COVID-19 pneumonia. A systematic review and validating cohort.Medicina clinica · 2023Pooled it
- The diagnostic performance of lung ultrasound for detecting COVID-19 in emergency departments: A systematic review and meta-analysis.Journal of clinical ultrasound : JCU · 2022Pooled it
- Thoracic imaging tests for the diagnosis of COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Ultrasound findings of lung ultrasonography in COVID-19: A systematic review.European journal of radiology · 2022Pooled it
- Digital imaging, technologies and artificial intelligence applications during COVID-19 pandemic.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021Pooled it
- Association of Lung Ultrasound Score with Mortality and Severity of COVID-19: A Meta-Analysis and Trial Sequential Analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- Lung ultrasound performed by primary care physicians as a predictive and diagnostic tool in COVID-19 patients.NPJ primary care respiratory medicine · 2026Observational
- Lung ultrasound in cardiac rehabilitation: expert consensus on protocols, clinical use, and integration into patient management from the working group on cardiac rehabilitation and cardiovascular prevention of the Italian society of cardiology.Heart failure reviews · 2025Review
- Pulmonary ultrasound in COVID-19 and non-COVID-19 pneumonia in South Africa: An observational study.African journal of thoracic and critical care medicine · 2025Article
- Lung ultrasound score severity cut-off points in COVID-19 pneumonia. A systematic review and validating cohort.Medicina clinica (English ed.) · 2023Article
- Lung ultrasound national report (LUNARE PROJECT) by the Italian Society of Internal Medicine (SIMI).Internal and emergency medicine · 2023Article
- Point-of-care Lung Ultrasound, Lung CT and NEWS to Predict Adverse Outcomes and Mortality in COVID-19 Associated Pneumonia.Journal of intensive care medicine · 2022Article
- Lung ultrasound in the follow-up of severe COVID-19 pneumonia: six months evaluation and comparison with CT.Internal and emergency medicine · 2022Observational
- Lung ultrasound as a screening tool for SARS-CoV-2 infection in surgical patients.Journal of clinical ultrasound : JCU · 2022Article
- Time course of lung ultrasound findings in patients with COVID-19 pneumonia and cardiac dysfunction.The ultrasound journal · 2022Article
- Review of COVID-19 testing and diagnostic methods.Talanta · 2022Review
- From the Triage to the Intermediate Area: A Simple and Fast Model for COVID-19 in the Emergency Department.International journal of environmental research and public health · 2022Article
- Diagnostic Performance of Antigen Rapid Diagnostic Tests, Chest Computed Tomography, and Lung Point-of-Care-Ultrasonography for SARS-CoV-2 Compared with RT-PCR Testing: A Systematic Review and Network Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Role of Lung Ultrasound in the Management of Patients with Suspected SARS-CoV-2 Infection in the Emergency Department.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to explore the role of lung ultrasound (LUS) in the diagnosis of SARS-CoV-2 infection and to verify its utility in the prediction of lung disease's severity and outcome. Fifty-three consecutive patients presenting to the Emergency Department of Santa Maria delle Grazie Hospital with high suspicion of SARS-CoV-2 infection underwent diagnostic test for SARS-CoV-2 on samples obtained from nasopharyngeal swab as well as complete proper diagnostic work-up that included clinical evaluation, laboratory tests, blood gas analyses, chest CT and LUS. A semiquantitative analysis of B-lines distribution was performed to calculate the LUS score. Patients were divided into two groups according to the results of both SARS-CoV-2 diagnostic test and other exams (Group A = pneumonia due to SARS-CoV2 infection vs Group B = no SARS-CoV2 infection and another definite diagnosis). LUS showed an excellent accuracy in predicting the diagnosis of SARS-CoV-2 infection (area under the ROC curve of 0.92 with a sensibility of 73% and a specificity of 89% a the cut-off of 12.5). LUS score was more impaired in SARS-CoV-2 patients (18.1 ± 6.0 vs 7.6 ± 5.9, p < 0.00001) and it is significantly negatively correlated with PF ratio values (r = - 0.719, p < 0.0001). An intrahospital mortality rate of 46% was found; patients with adverse outcome had significant higher value of LUS, PF, LDH, and APACHE II score. None of these parameters was predictive of mortality. LUS is a useful tool for the early detection of SARS-CoV-2 infection and for the evaluation of the disease severity, but does not predict mortality. Further studies with repeated evaluations of LUS score are needed to further explore the role of LUS in the assessment of severity in SARS-CoV-2 disease and in the monitoring of the response to treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.