Evidence map›Paper›PMID 33011905›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2021

Point-of-care multiplex-PCR enables germ identification in haemolytic uremic syndrome 94 h earlier than stool culture.

Luis Hernán Llano López, Pablo Melonari, Stephan Gehring, Daniel Schreiner, Sandra Grucci, Sofía Pérez Araujo, Lorena Di Pauli, Christina Oetzmann von Sochaczewski, Arne Schröder, Laura Piovano

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Luis Hernán Llano LópezServicio de Terapia Intensiva Infantil, Hospital Pediátrico Dr. Humberto Notti, Mendoza, Argentina. luishernanllano@hotmail.com.ORCID http://orcid.org/0000-0001-9458-8498
Pablo MelonariServicio de Infectología, Hospital Pediátrico Dr. Humberto Notti, Mendoza, Argentina.
Stephan GehringZentrum für Kinder- und Jugendmedizin, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.ORCID https://orcid.org/0000-0002-9755-9155
Daniel SchreinerZentrum für Kinder- und Jugendmedizin, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.
Sandra GrucciServicio de Inmunoserología, Departamento de Bioquímica, Hospital Pediátrico Dr. Humberto Notti, Mendoza, Argentina.
Sofía Pérez AraujoServicio de Microbiología, Departamento de Bioquímica, Hospital Pediátrico Dr. Humberto Notti, Mendoza, Argentina.
Lorena Di PauliServicio de Infectología, Hospital Pediátrico Dr. Humberto Notti, Mendoza, Argentina.
Christina Oetzmann von SochaczewskiKlinik und Poliklinik für Kinderchirurgie, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.ORCID https://orcid.org/0000-0002-3469-777X
Arne SchröderKlinik für Kinder- und Jugendmedizin, Elisabeth-Krankenhaus, Essen, Germany.ORCID https://orcid.org/0000-0003-1552-6163
Laura PiovanoServicio de Terapia Intensiva Infantil, Hospital Pediátrico Dr. Humberto Notti, Mendoza, Argentina.
Johannes Gutenberg University Mainz · DEInfant Foundation · ARElisabeth-Krankenhaus Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haemolytic uremic syndrome often affects children causing a relevant morbidity and mortality. We compared the time to diagnosis by multiplex-PCR and stool culture in 15 children from two centres. Multiplex-PCR accelerated the time to diagnosis by 94 (95% confidence interval, 80-119; P = 0.0007) hours. Multiplex-PCR offers a time advantage of stool culture that may aid in earlier identification of outbreak clusters.

Indexed as

Multiplex Polymerase Chain ReactionPoint-of-Care TestingChildChild, PreschoolEarly DiagnosisEscherichia coli InfectionsFecesHemolytic-Uremic SyndromeHumansInfantRetrospective StudiesShiga-Toxigenic Escherichia coliBiofireChildrenGastrointestinal panelShiga-like toxin

Identifiers

PMID33011905
OpenAlexW3089451071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.