Evidence map›Paper›PMID 33011892›Full record

ArticleMolecular biology reports2020

Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl

Anibah Khalid, Umme Aimen Abbasi, Sanila Amber, Sumera, Fatima Javed Mirza, Muhammad Asif, Aneela Javed, Saadia Zahid

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Deciphering Neuroprotective Effect ofCurrent drug targets · 2024
    Review
  7. Article
  8. Ameliorative effects of probiotics in AlClApplied microbiology and biotechnology · 2023
    Article
  9. Article
  10. Article
  11. Frontiers in pharmacology · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anibah KhalidDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Umme Aimen AbbasiDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Sanila AmberDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
SumeraDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Fatima Javed MirzaDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Muhammad AsifDepartment of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
Aneela JavedDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Saadia ZahidDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan. saadiazahid@hotmail.com.ORCID http://orcid.org/0000-0003-1667-554X
National University of Sciences and Technology · PKArmed Forces Institute of Pathology · PKNational University of Technology · PK

Funding

Higher Education Commision, Pakistan NRPU-5019
6 · The paper itself

Abstract

Methylphenidate (MPH), a psychotropic medication is commonly used for children with attention deficit hyperactivity disorder (ADHD). In this study we elucidated the neuroprotective and anti-inflammatory effects of MPH and Rosmarinus officinalis (rosemary) extract, an ancient aromatic herb with several applications in traditional medicine. Briefly, six groups of mice (n = 8 each group), were specified for the study and behavioral analysis was performed to analyze spatial memory followed by histological assessment and gene expression analysis of synaptic (Syn I, II and III) and inflammatory markers (IL-6, TNFα and GFAP) via qRT-PCR, in an AlCl

Indexed as

Aluminum ChlorideAnimalsCognitionGene Expression RegulationInflammationMaleMethylphenidateMiceMice, Inbred BALB CNeurotoxicity SyndromesPlant ExtractsRosmarinusSynapsesAluminum ChlorideMethylphenidatePlant ExtractsInflammationMethylphenidateNeurodegenerationNeurotoxicityRosmarinus officinalis

Identifiers

PMID33011892
OpenAlexW3090093840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.