ArticleEuropean journal of applied physiology2021
The scaling of human basal and resting metabolic rates.
Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Passage-Dependent Size Distributions of Human-Derived Cells: Implications for Metabolic Assays.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Interactive effects of intrinsic and extrinsic factors on metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 4: evolution, thermal adaptation and unsupported theories of thermoregulation.European journal of applied physiology · 2024Review
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 3: Heat and cold tolerance during exercise.European journal of applied physiology · 2024Review
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 2: physiological measurements.European journal of applied physiology · 2023Review
- The 'faulty male' hypothesis for sex-biased mutation and disease.Current biology : CB · 2023Review
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 1: Foundational principles and theories of regulation.European journal of applied physiology · 2023Review
- Predicting resting energy expenditure: a critical appraisal.European journal of clinical nutrition · 2023Article
- Article
- Pulmonary Capacity, Blood Composition and Metabolism among Coal Mine Workers in High- and Low-Altitude Aboveground and Underground Workplaces.International journal of environmental research and public health · 2022Article
- A General Biphasic Bodyweight Model for Scaling Basal Metabolic Rate, Glomerular Filtration Rate, and Drug Clearance from Birth to Adulthood.The AAPS journal · 2022Article
- Methodologies for energy evaluation of pig and poultry feeds: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Article
- Scaling the peak and steady-state aerobic power of running and walking humans.European journal of applied physiology · 2021Article
- The development of accumulated OEuropean journal of applied physiology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn tachymetabolic species, metabolic rate increases disproportionately with body mass, and that inter-specific relationship is typically modelled allometrically. However, intra-specific analyses are less common, particularly for healthy humans, so the possibility that human metabolism would also scale allometrically was investigated.
methodsBasal metabolic rate was determined (respirometry) for 68 males (18-40 years; 56.0-117.1 kg), recruited across five body-mass classes. Data were collected during supine, normothermic rest from well-rested, well-hydrated and post-absorptive participants. Linear and allometric regressions were applied, and three scaling methods were assessed. Data from an historical database were also analysed (2.7-108.9 kg, 4811 males; 2.0-96.4 kg, 2364 females).
resultsBoth linear and allometric functions satisfied the statistical requirements, but not the biological pre-requisite of an origin intercept. Mass-independent basal metabolic data beyond the experimental mass range were not achieved using linear regression, which yielded biologically impossible predictions as body mass approached zero. Conversely, allometric regression provided a biologically valid, powerful and statistically significant model: metabolic rate = 0.739 * body mass
conclusionIt was established that basal and resting metabolic rates scale allometrically with body mass in humans from 10-117 kg, with an exponent of 0.50-0.55. It was also demonstrated that ratiometric scaling yielded invalid metabolic predictions, even within the relatively narrow experimental mass range. Those outcomes have significant physiological implications, with applications to exercising states, modelling, nutrition and metabolism-dependent pharmacological prescriptions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.