ReviewChest2021
Dyspnea, Acute Respiratory Failure, Psychological Trauma, and Post-ICU Mental Health: A Caution and a Call for Research.
Review in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07701850 (The Influence of Standard Ventilator Setting Adjustments on Dyspnea Experienced in Awake Mechanically-ventilated Patients), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Standard Ventilator Setting Adjustments on Dyspnea Experienced in Awake Mechanically-ventilated Patients: A Pilot Study
Who cites it
24 citing papers in PubMed.
- The Personhood Pentadigm: A transcultural framework for analyzing existential distress in palliative care.International journal of nursing sciences · 2026Article
- Validation of the Korean Versions of the Scale of Food Allergy Anxiety and the Food Allergy Anxiety Scales for Children and Parents.Allergy, asthma & immunology research · 2026Article
- Trajectories of emotional and physical distress during ICU stay and their association with clinical factors and cognitive status at discharge.Scientific reports · 2026Observational
- Dyspnea is related to clinical outcomes in patients weaning from invasive mechanical ventilation with tracheostomy: a multicenter prospective study.Critical care (London, England) · 2026Observational
- Targeting dyspnoea through exercise intensity: insights from pulmonary rehabilitation and beyond, a narrative review.Frontiers in rehabilitation sciences · 2026Review
- Characteristics of symptoms and establishment of a predictive model for PICS in mechanically ventilated patients with severe pneumonia: a retrospective study.European journal of medical research · 2025Article
- Target for Today: Air Hunger.American journal of respiratory and critical care medicine · 2025Article
- Development and validation of a predictive model for depression risk in patients with amyotrophic lateral sclerosis.Frontiers in neurology · 2025Article
- Assessment of breathlessness: a pulmonologist's perspective - short of breath, but not short of answers.Breathe (Sheffield, England) · 2025Review
- A non-invasive method to monitor respiratory muscle effort during mechanical ventilation.Journal of clinical monitoring and computing · 2024Article
- The occurrence mechanism, assessment, and non-pharmacological treatment of dyspnea.Medical review (2021) · 2024Review
- Occurrence, co-occurrence and persistence of symptoms of depression and post-traumatic stress disorder in survivors of COVID-19 critical illness.European journal of psychotraumatology · 2024Observational
- Upper Airway-Related Symptoms According to Mental Illness and Sleep Disorders among Workers Employed by a Large Non-Profit Organization in the Mountain West Region of the United States.International journal of environmental research and public health · 2023Article
- Dyspnea in the ICU: It Is Difficult to See What Patients Feel.American journal of respiratory and critical care medicine · 2023Article
- DYSPNEA AND MECHANICAL VENTILATION: APPLYING PHYSIOLOGY TO GUIDE THERAPY.Transactions of the American Clinical and Climatological Association · 2023Article
- Dyspnea and Mechanical Ventilation: The Emperor Has No Clothes.American journal of respiratory and critical care medicine · 2022Article
- Post-Discharge Depression Status for Survivors of Extracorporeal Membrane Oxygenation (ECMO): Comparison of Veno-Venous ECMO and Veno-Arterial ECMO.International journal of environmental research and public health · 2022Article
- Myths and Misconceptions of Airway Pressure Release Ventilation: Getting Past the Noise and on to the Signal.Frontiers in physiology · 2022Review
- An Empirical Analysis of the Role of Piano Performance in Alleviating Psychological Trauma in People with Psychological Isolation Disorder.Occupational therapy international · 2022Article
- Sevoflurane in combination with esketamine is an effective sedation regimen in COVID-19 patients enabling assisted spontaneous breathing even during prone positioning.Anaesthesiology intensive therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dyspnea is an uncomfortable sensation with the potential to cause psychological trauma. Patients presenting with acute respiratory failure, particularly when tidal volume is restricted during mechanical ventilation, may experience the most distressing form of dyspnea known as air hunger. Air hunger activates brain pathways known to be involved in posttraumatic stress disorder (PTSD), anxiety, and depression. These conditions are considered part of the post-intensive care syndrome. These sequelae may be even more prevalent among patients with ARDS. Low tidal volume, a mainstay of modern therapy for ARDS, is difficult to avoid and is likely to cause air hunger despite sedation. Adjunctive neuromuscular blockade does not prevent or relieve air hunger, but it does prevent the patient from communicating discomfort to caregivers. Consequently, paralysis may also contribute to the development of PTSD. Although research has identified post-ARDS PTSD as a cause for concern, and investigators have taken steps to quantify the burden of disease, there is little information to guide mechanical ventilation strategies designed to reduce its occurrence. We suggest such efforts will be more successful if they are directed at the known mechanisms of air hunger. Investigation of the antidyspnea effects of sedative and analgesic drugs commonly used in the ICU and their impact on post-ARDS PTSD symptoms is a logical next step. Although in practice we often accept negative consequences of life-saving therapies as unavoidable, we must understand the negative sequelae of our therapies and work to minimize them under our primary directive to "first, do no harm" to patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.