Evidence map›Paper›PMID 33010878›Full record

ArticleAmerican journal of surgery2021

Association between age and disease specific mortality in medullary thyroid cancer.

Zeyad T Sahli, Joseph K Canner, Martha A Zeiger, Aarti Mathur

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  16. Independent Validation of the International Grading System for Medullary Thyroid Carcinoma: A Single Institution Experience.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023
    Article
  17. Article
  18. Operative Management of Thyroid Disease in Older Adults.Journal of the Endocrine Society · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zeyad T SahliDepartment of Surgery, The University of Virginia Health System, P.O. Box 800681, Charlottesville, VA, 22908, USA.
Joseph K CannerEndocrine Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 606, Baltimore, MD, 21287, USA.
Martha A ZeigerSurgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Aarti MathurEndocrine Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 606, Baltimore, MD, 21287, USA. Electronic address: amathu10@jhmi.edu.
Johns Hopkins University · USNational Institutes of Health · USUniversity of Virginia Health System · US

Funding

Training and Development of Outstanding Surgeon ScientistsZIEBC011992 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZEIGER, MARTHA · 2020 to 2024
$9.6M
Association of Fraility with Post thyroidectomy alterations in Voice, Swallowing, and Quality of LifeK23AG053429 · NIA · JOHNS HOPKINS UNIVERSITY · PI MATHUR, AARTI · 2017 to 2022
$1.0M
Intramural NIH HHS ZIE BC011992NIA NIH HHS K23 AG053429
6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC).

methodSurveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18-64, 65-79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression.

resultsAmong 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83-4.63; p < 0.001 and HR: 6.70, 95%CI: 3.69-12.20; p < 0.001). Extent of surgery or lymphadenectomy did not affect DSM.

conclusionsIncreased age is an independent predictor of DSM in patients with MTC.

Indexed as

ThyroidectomyAdolescentAdultAgedAged, 80 and overAge FactorsCarcinoma, NeuroendocrineFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesSEER ProgramThyroid GlandAgingDisease-specific mortalityElderlyMedullary thyroid cancerOlder adultsSurvival

Identifiers

PMID33010878
PMCPMC9169693
OpenAlexW3088963933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.