ArticleVirology2020
Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD.
Article in Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Genetic and Phylogenetic Characterization of Influenza D Viruses From South Korean Cattle, 2022-2023.Transboundary and emerging diseases · 2026Article
- Distinct influenza interfaces in cattle: repeated spillovers of highly pathogenic avian influenza A(H5N1) from wild birds and enzootic circulation of influenza D virus.Frontiers in cellular and infection microbiology · 2026Review
- Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms.Transboundary and emerging diseases · 2026Article
- Evaluating the Diagnostic Performance of Long-Read Metagenomic Sequencing Compared to Culture and Antimicrobial Susceptibility Testing for Detection of Bovine Respiratory Bacteria and Indicators of Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025Article
- Sparse Evidence of Influenza C on US Dairy and Beef Cattle Farms.Influenza and other respiratory viruses · 2025Article
- Epidemiological Investigation and Phylogenetic Analysis of Bovine Respiratory Disease Complex in Northern China.Veterinary medicine and science · 2025Article
- Differential tissue tropism and transmission efficiency of two dominant influenza D clades with overlapping but distinct receptor binding fine specificities in ferrets.PLoS pathogens · 2025Article
- Seroprevalence of influenza C and D virus infections among cattle in Japan.Veterinary and animal science · 2025Article
- A Comprehensive Review: Bovine Respiratory Disease, Current Insights into Epidemiology, Diagnostic Challenges, and Vaccination.Veterinary sciences · 2025Review
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- Bovine Parainfluenza Virus 3 and Bovine Respiratory Syncytial Virus: Dominant Viral Players in Bovine Respiratory Disease Complex among Serbian Cattle.Animals : an open access journal from MDPI · 2024Article
- Prevalence and characterization of seven-segmented influenza viruses in bovine respiratory disease complex.Virology · 2023Article
- Influenza C and D Viruses Demonstrated a Differential Respiratory Tissue Tropism in a Comparative Pathogenesis Study in Guinea Pigs.Journal of virology · 2023Article
- Presence of co-infection between bovine leukemia virus and bovine herpesvirus 1 in herds vaccinated against bovine respiratory complex.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease.Viruses · 2023Article
- Reduction in Mortality of Calves with Bovine Respiratory Disease in Detection with Influenza C and D Virus.Animals : an open access journal from MDPI · 2022Article
- Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence.Veterinary research · 2022Review
- Pathophysiology of Influenza D Virus Infection in Specific-Pathogen-Free Lambs with or without PriorViruses · 2022Article
- Cattle influenza D virus in Brazil is divergent from established lineages.Archives of virology · 2022Article
- Evolutionary and temporal dynamics of emerging influenza D virus in Europe (2009-22).Virus evolution · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to play a role in BRD. However, there are contradicting reports about the association of IDV and ICV to BRD. Using the largest cohort study (cattle, n = 599) to date we investigated the association of influenza viruses in cattle with BRD. Cattle were scored for respiratory symptoms and pooled nasal and pharyngeal swabs were tested for bovine viral diarrhea virus, bovine herpesvirus 1, bovine respiratory syncytial virus, bovine coronavirus, ICV and IDV by real-time PCR. Cattle that have higher viral loads of IDV and ICV also have greater numbers of co-infecting viruses than controls. More strikingly, 2 logs higher IDV viral RNA in BRD-symptomatic cattle that are co-infected animals than those infected with IDV alone. Our results strongly suggest that ICV and IDV may be significant contributors to BRD.
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