Evidence map›Paper›PMID 33010567›Full record

ArticleJournal of affective disorders2021

Mood symptoms and impairment due to substance use: A network perspective on comorbidity.

Daniel P Moriarity, Corinne P Bart, Allison Stumper, Payton Jones, Lauren B Alloy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel P MoriarityDepartment of Psychology, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA 19122, United States.
Corinne P BartDepartment of Psychology, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA 19122, United States.
Allison StumperDepartment of Psychology, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA 19122, United States.
Payton JonesDepartment of Psychology, Harvard University, United States.
Lauren B AlloyDepartment of Psychology, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA 19122, United States. Electronic address: lalloy@temple.edu.

Funding

Risk for Bipolar Disorder: Reward-related Brain Function & Social RhythmsR01MH077908 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2007 to 2017
$5.7M
Integrated Reward-Inflammation Model Of First Onset Of Major Depression In Adolescence SupplementR01MH123473 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Social and Circadian Rhythms, Reward Sensitivity, and Risk for Bipolar DisorderR01MH102310 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2014 to 2017
$1.6M
Integrated Reward Sensitivity and Rumination Model of Stress Reactivity and Depression SymptomsF31MH122116 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI MORIARITY, DANIEL P · 2020 to 2021
$58k
NIMH NIH HHS F31 MH122116NIMH NIH HHS R01 MH077908NIMH NIH HHS R01 MH102310NIMH NIH HHS R01 MH123473
6 · The paper itself

Abstract

backgroundMood disorders and problematic substance use co-occur and confer reciprocal risk for each other. Few studies use analytic approaches appropriate for testing whether specific features of one disorder confer risk for the other.

methods445 participants (59.8% female, Mean age = 20.3 years) completed measures of depression and hypo/mania symptoms and substance use-related impairment; 330 had complete data at follow-up. Of these, 28% reported a history of depression, 4% of bipolar spectrum disorder, 11% of substance use disorder, and 55% reported substance-related impairment. Symptoms and domains of substance-related impairment were modeled in cross-sectional and cross-lagged panel network models.

resultsImpulsive and interpersonal impairment were most highly comorbid with mood symptoms. Suicidal ideation, sadness, decreased need for sleep, and guilt were the symptoms most highly comorbid with impairment. Interpersonal impairment due to substance use was the strongest cross-construct predictor of mood symptoms and suicidal ideation was most predictive of impairment. Social, intrapersonal, and physical impairment due to substance use were most predicted by previous mood symptoms and decreased need for sleep, guilt, and euphoria were most strongly predicted by past impairment. LIMITATIONS: Measures do not assess all mood symptoms, participants with low reward sensitivity were excluded, only self-report measures were used, and some variables were single-items.

conclusionsComponents of these syndromes that confer cross-construct risk might not be the same components that are predicted by the other construct. The bidirectional relationship between mood symptoms and problematic substance use might be better conceptualized at the element, rather than diagnostic, level.

Indexed as

Bipolar DisorderSubstance-Related DisordersAdultComorbidityCross-Sectional StudiesFemaleHumansMaleMood DisordersYoung AdultBipolar disorderComorbidityDepressionHypomaniaSubstance use

Identifiers

PMID33010567
PMCPMC7704896

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.