Evidence map›Paper›PMID 33010502›Full record

ArticleWorld neurosurgery2020

Magnetization Transfer Ratio and Morphometrics of the Spinal Cord Associates with Surgical Recovery in Patients with Degenerative Cervical Myelopathy.

Monica Paliwal, Kenneth A Weber, Benjamin S Hopkins, Donald R Cantrell, Mark A Hoggarth, James M Elliott, Nader S Dahdaleh, Sean Mackey, Todd D Parrish, Yasin Dhaher and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Evaluating tissue injury in cervical spondylotic myelopathy with spinal cord MRI: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
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  18. Microstructural changes in the spinal cord of adults with cerebral palsy.Developmental medicine and child neurology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Monica PaliwalDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Electronic address: monicapaliwal1@gmail.com.
Kenneth A WeberSystems Neuroscience and Pain Laboratory, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California, USA.
Benjamin S HopkinsDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Donald R CantrellDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Mark A HoggarthDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
James M ElliottDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Faculty of Medicine and Health, University of Sydney, Kolling Institute of Medical Research, St. Leonards, New South Wales, Australia.
Nader S DahdalehDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Sean MackeySystems Neuroscience and Pain Laboratory, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California, USA.
Todd D ParrishDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Yasin DhaherDepartment of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Zachary A SmithDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Northwestern University · USStanford University · USUniversity of Oklahoma Health Sciences Center · USThe University of Texas Southwestern Medical Center · US

Funding

Interdisciplinary Graduate Education in Movement and Rehabilitation Sciences-RenewalT32EB009406 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JULIUS P DEWALD, JUN YAO · 2009 to 2026
$2.2M
Neuroimaging and Mentoring in Translational Pain ResearchK24DA029262 · NIDA · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2010 to 2019
$1.9M
Radiographic markers of clinical function in Cervical Spondylotic MyelopathyK23NS091430 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SMITH, ZACHARY · 2017 to 2021
$1.1M
Neuroimaging-Based Brain and Spinal Cord Biomarkers for Cervical RadiculopathyK23NS104211 · NINDS · STANFORD UNIVERSITY · PI WEBER, KENNETH ARNOLD · 2018 to 2022
$875k
NIDA NIH HHS K24 DA029262NINDS NIH HHS K23 NS091430NINDS NIH HHS K23 NS104211NINDS NIH HHS L30 NS108301
6 · The paper itself

Abstract

objectivesWe assessed the prognostic value of the preoperative magnetization transfer ratio (MTR) and morphometrics of the spinal cord in patients with degenerative cervical myelopathy (DCM) in a longitudinal cohort study.

methodsThirteen subjects with DCM underwent 3T magnetization transfer imaging. The MTR was calculated for the spinal cord regions and specific white matter tracts. Morphometric measures were extracted. Clinical (modified Japanese Orthopaedics Association [mJOA] and Nurick scale scores) and health-related quality of life scores were assessed before and after cervical decompression surgery. The association between the magnetic resonance imaging (MRI) metrics and postoperative recovery was assessed (Spearman's correlation). Receiver operating characteristics were used to assess the accuracy of MRI metrics in identifying ≥50% recovery in function.

resultsPreoperative anterior cord MTRs were associated with recovery in mJOA scores (ρ = 0.608; P = 0.036; area under the curve [AUC], 0.66). Preoperative lateral cord MTR correlated with the neck disability index (ρ = 0.699; P = 0.011) and pain interference scale (ρ = 0.732; P = 0.007). Preoperative rubrospinal tract MTR was associated with mJOA score recovery (ρ = 0.573; P = 0.041; AUC, 0.86). Preoperative corticospinal tract and reticulospinal MTRs were related to recovery in pain interference scores (ρ = 0.591; P = 0.033; and ρ = 0.583; P = 0.035, respectively). Eccentricity of the cord was associated with Nurick scores (ρ = 0.606; P = 0.028) and mJOA scores (ρ = 0.651; P = 0.025; AUC, 0.92).

conclusionsPreoperative MTR and eccentricity measurements of the spinal cord have prognostic value in assessing the response to surgery and recovery in patients with DCM. Advanced MRI and atlas-based postprocessing techniques can inform interventions and advance the healthcare received by patients with DCM.

Indexed as

Cohort StudiesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPostoperative PainSensitivity and SpecificitySpinal Cord DiseasesSpondylosisTreatment OutcomeWhite MatterDegenerative spondylotic myelopathyMagnetic resonance imagingPrognostic utilitySpinal cordSurgical outcomes

Identifiers

PMID33010502
PMCPMC8312860
OpenAlexW3091567608

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.