Evidence map›Paper›PMID 33010231›Full record

Trial reportMolecular therapy : the journal of the American Society of Gene Therapy2021

CART19-BE-01: A Multicenter Trial of ARI-0001 Cell Therapy in Patients with CD19

Valentín Ortíz-Maldonado, Susana Rives, Maria Castellà, Anna Alonso-Saladrigues, Daniel Benítez-Ribas, Miguel Caballero-Baños, Tycho Baumann, Joan Cid, Enric Garcia-Rey, Cristina Llanos and 30 more

Registry-linked trialOpen access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Molecular therapy : the journal of the American Society of Gene Therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07502118 (An Open-Label, Multicenter Phase 2-3 Clinical Study of Anti-CD19 Chimeric Antigen Receptor T Cells), which is not on this map. Cited by 101 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 9 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07502118 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

An Open-Label, Multicenter Phase 2-3 Clinical Study of Anti-CD19 Chimeric Antigen Receptor T Cells (Talikabtagene Autoleucel) in Patients With Relapsed/Refractory B-Cell Malignancies (NexCAR19)

TypeinterventionalSponsorHealth Institutes of TurkeyRan2025 to 2030Enrolled40ConditionsRelapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), High-grade B-cell Lymphoma (HGBCL)ArmsTalikabtagene Autoleucel
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 9 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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  19. Emerging strategies to reduce the side effects of CAR-T cell therapy: focusing on gene editing and nanotechnology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 5 institutions in 1 country.

Valentín Ortíz-MaldonadoDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
Susana RivesDepartment of Hematology/Oncology, Hospital Sant Joan de Déu, Barcelona, Spain; Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain.
Maria CastellàDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain.
Anna Alonso-SaladriguesDepartment of Hematology/Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
Daniel Benítez-RibasInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Miguel Caballero-BañosDepartment of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Tycho BaumannDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain.
Joan CidInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Apheresis & Cell Therapy Unit, Department of Hemotherapy and Hemostasis, Hospital Clínic de Barcelona, Barcelona, Spain.
Enric Garcia-ReyBanc de Sang i Teixits, Barcelona, Spain.
Cristina LlanosClinical Research Unit, Fundació Sant Joan de Déu, Barcelona, Spain.
Montserrat TorrebadellInstitut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain; Laboratory of Hematology, Hospital Sant Joan de Déu, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) , Barcelona, Spain.
Neus VillamorInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Hematopathology Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
Eva GinéDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
Marina Díaz-BeyáDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain.
Laia GuardiaDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
Mercedes MontoroDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
Albert CatalàDepartment of Hematology/Oncology, Hospital Sant Joan de Déu, Barcelona, Spain; Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain.
Anna FauraDepartment of Hematology/Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
E Azucena GonzálezDepartment of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Marta Español-RegoDepartment of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Nela Klein-GonzálezDepartment of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Laia AlsinaClinical Immunology Platform Clínic-Sant Joan de Déu, Barcelona, Spain.
Pedro CastroInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Medical Intensive Care Unit, Hospital Clínic de Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain.
Iolanda JordanInstitut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain.
Sara FernándezMedical Intensive Care Unit, Hospital Clínic de Barcelona, Barcelona, Spain.
Federico RamosDepartment of Neurology, Hospital Sant Joan de Déu, Barcelona, Spain.
Guillermo SuñéDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain.
Unai PerpiñáInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Laboratory of Stem Cells and Regenerative Medicine, Department of Biomedicine, Production and Validation Center of Advanced Therapies (Creatio), University of Barcelona, Barcelona, Spain.
Josep M CanalsInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Laboratory of Stem Cells and Regenerative Medicine, Department of Biomedicine, Production and Validation Center of Advanced Therapies (Creatio), University of Barcelona, Barcelona, Spain.
Miquel LozanoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Apheresis & Cell Therapy Unit, Department of Hemotherapy and Hemostasis, Hospital Clínic de Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain.
Esteve TriasAdvanced Therapies Unit, Hospital Clínic de Barcelona, Barcelona, Spain.
Andrea ScaliseDepartment of Pharmacology, Hospital Clínic de Barcelona, Barcelona, Spain.
Sara VareaDepartment of Pharmacology, Hospital Clínic de Barcelona, Barcelona, Spain.
Joaquín Sáez-PeñataroUniversity of Barcelona, Barcelona, Spain; Department of Pharmacology, Hospital Clínic de Barcelona, Barcelona, Spain.
Ferran TorresInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Department of Pharmacology, Hospital Clínic de Barcelona, Barcelona, Spain.
Gonzalo CalvoAdvanced Therapies Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Department of Pharmacology, Hospital Clínic de Barcelona, Barcelona, Spain.
Jordi EsteveDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; University of Barcelona, Barcelona, Spain; Institute of Research Josep Carreras, Barcelona, Spain.
Álvaro Urbano-IspizuaDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; University of Barcelona, Barcelona, Spain; Institute of Research Josep Carreras, Barcelona, Spain.
Manel JuanInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain; Clinical Immunology Platform Clínic-Sant Joan de Déu, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Advanced Therapies Unit, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address: mjuan@clinic.cat.
Julio DelgadoDepartment of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain; University of Barcelona, Barcelona, Spain. Electronic address: jdelgado@clinic.cat.
Hospital Clínic de Barcelona · ESHospital Sant Joan de Déu Barcelona · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESBanc de Sang i Teixits · ESSant Joan de Déu Research Foundation · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the administration of ARI-0001 cells (chimeric antigen receptor T cells targeting CD19) in adult and pediatric patients with relapsed/refractory CD19

Indexed as

Immunotherapy, AdoptiveAntigens, CD19Cell- and Tissue-Based TherapyDrug Resistance, NeoplasmFemaleHumansMaleNeoplasm GradingNeoplasmsNeoplasm StagingReceptors, Chimeric AntigenRecurrenceT-LymphocytesAntigens, CD19Receptors, Chimeric AntigenA3B1ALLARI-0001CART-cellsCD19NHL

Identifiers

PMID33010231
PMCPMC7854276
OpenAlexW3088527073

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.